Evidence map›Paper›PMID 28726862›Full record

ArticleChemical communications (Cambridge, England)2017

A targeted delivery strategy for the development of potent trypanocides.

Heeren M Gordhan, Jillian E Milanes, Yijian Qiu, Jennifer E Golden, Kenneth A Christensen, James C Morris, Daniel C Whitehead

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical communications (Cambridge, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Heeren M GordhanDepartment of Chemistry, Clemson University, Clemson, SC, USA. dwhiteh@clemson.edu.
Jillian E MilanesEukaryotic Pathogens Innovation Center, Department of Genetics and Biochemistry, Clemson University, Clemson, SC, USA. jmorri2@clemson.edu.
Yijian QiuEukaryotic Pathogens Innovation Center, Department of Genetics and Biochemistry, Clemson University, Clemson, SC, USA. jmorri2@clemson.edu.
Jennifer E GoldenDepartment of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin, Madison, WI, USA.ORCID http://orcid.org/0000-0002-6813-3710
Kenneth A ChristensenDepartment of Chemistry and Biochemistry, Brigham Young University, Provo, UT, USA.
James C MorrisEukaryotic Pathogens Innovation Center, Department of Genetics and Biochemistry, Clemson University, Clemson, SC, USA. jmorri2@clemson.edu.ORCID http://orcid.org/0000-0003-2515-5714
Daniel C WhiteheadDepartment of Chemistry, Clemson University, Clemson, SC, USA. dwhiteh@clemson.edu.ORCID http://orcid.org/0000-0001-6881-2628

Funding

The role of acetate fermentation in Entamoeba histolytica growth and infectionP20GM109094 · NIGMS · CLEMSON UNIVERSITY · PI KOZUBOWSKI, LUKASZ · 2016 to 2020
$10.4M
pH and glucose sensing in Trypanosoma brucei glycosomesR21AI105656 · NIAID · CLEMSON UNIVERSITY · PI CHRISTENSEN, KENNETH A, MORRIS, JAMES CULVIN · 2014 to 2015
$382k
NIAID NIH HHS R21 AI105656NIGMS NIH HHS P20 GM109094
6 · The paper itself

Abstract

A new drug delivery strategy was investigated for the development of potent anti-parasitic compounds against Trypanosoma brucei, the causative agent of African sleeping sickness. Thus, potent in vitro hexokinase inhibitors were rendered cytotoxic by appending a tripeptide peroxosomal targeting sequence that facilitated delivery of the molecular cargo to the appropriate organelle in the parasite.

Identifiers

PMID28726862
PMCPMC5576345

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.