ArticleJournal of perinatology : official journal of the California Perinatal Association2017
Predominant area of brain lesions in neonates with herpes simplex encephalitis.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed, 20 citations in OpenAlex.
- Cranial ultrasound in neonatal brain infections.Developmental medicine and child neurology · 2025Review
- Diagnostic imaging of Bacillus cereus brain infection in newborns.Pediatric radiology · 2025Article
- Expert consensus on the clinical practice of neonatal brain magnetic resonance imaging.Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2022Article
- Uncommon acute neuroimaging findings in severe neonatal herpes simplex virus 2 and consequences of delayed diagnosis.Emergency radiology · 2021Article
- Non-congenital viral infections of the central nervous system: from the immunocompetent to the immunocompromised child.Pediatric radiology · 2020Review
- Clinical features of gingivostomatitis due to primary infection of herpes simplex virus in children.BMC infectious diseases · 2020Article
- Zika Virus Infection in the Developing Mouse Produces Dramatically Different Neuropathology Dependent on Viral Strain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveNonspecific manifestations and a varied distribution of brain lesions can delay the diagnosis of herpes simplex encephalitis (HSE) in neonates. The aim of this study was to report predominant brain lesions in neonatal HSE, and then to investigate the association between pattern of predominant brain lesions, clinical variables and neurodevelopmental outcome. STUDY
designA multicenter retrospective study was performed in neonates diagnosed with HSE between 2009 and 2014. Magnetic resonance (MR) images, including diffusion-weighted images, were obtained in the acute and chronic phase.
resultsThree predominant areas of brain injury could be defined based on characteristic MRI findings in 10 of the 13 infants (77%). The inferior frontal/temporal pole area was involved in five (38%) patients. The watershed distribution was present in six (46%) patients. Four (31%) infants involved the corticospinal tract area. No significant association was found between any predominant distribution of brain lesion pattern and sex, country, viral type or viral load. However, the corticospinal tract involvement was significantly associated with motor impairment (P=0.045).
conclusionThree predominant areas of brain lesion could be recognized in neonatal HSE. Recognition of those areas can improve prediction of neurodevelopmental outcome.
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