Evidence map›Paper›PMID 28726772›Full record

ArticleCell death & disease2017

Mice lacking NF-κB1 exhibit marked DNA damage responses and more severe gastric pathology in response to intraperitoneal tamoxifen administration.

Michael D Burkitt, Jonathan M Williams, Tristan Townsend, Rachael Hough, Carrie A Duckworth, D Mark Pritchard

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Michael D BurkittDepartment of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, The Henry Wellcome Laboratory, Liverpool, UK.
Jonathan M WilliamsPathology and Pathogen Biology, Royal Veterinary College, North Mymms, UK.
Tristan TownsendDepartment of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, The Henry Wellcome Laboratory, Liverpool, UK.
Rachael HoughDepartment of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, The Henry Wellcome Laboratory, Liverpool, UK.
Carrie A Duckworth
D Mark PritchardDepartment of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, The Henry Wellcome Laboratory, Liverpool, UK.
University of Liverpool · GBRoyal Veterinary College · GB

Funding

Wellcome Trust
6 · The paper itself

Abstract

Tamoxifen (TAM) has recently been shown to cause acute gastric atrophy and metaplasia in mice. We have previously demonstrated that the outcome of Helicobacter felis infection, which induces similar gastric lesions in mice, is altered by deletion of specific NF-κB subunits. Nfkb1

Indexed as

DNA DamageAnimalsFemaleGastric MucosaHelicobacter felisHelicobacter InfectionsMiceMice, KnockoutNF-kappa B p50 SubunitNF-kappa B p52 SubunitProto-Oncogene Proteins c-relSignal TransductionStomach DiseasesTamoxifenNF-kappa B p50 SubunitNF-kappa B p52 SubunitNfkb1 protein, mouseNfkb2 protein, mouseProto-Oncogene Proteins c-relTamoxifen

Identifiers

PMID28726772
PMCPMC5584614
OpenAlexW2951050565

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.