ArticleNature communications2017
Activity dependent feedback inhibition may maintain head direction signals in mouse presubiculum.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- In vivo hippocampal subfield volumes in bipolar disorder-A mega-analysis from The Enhancing Neuro Imaging Genetics through Meta-Analysis Bipolar Disorder Working Group.Human brain mapping · 2022Pooled it
- Ring attractor networks go full circle.Nature neuroscience · 2026Article
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- Medial entorhinal VIP-expressing interneurons receive input from the thalamic anterior dorsal nucleus and are critical for spatial memory.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Local origin of excitatory-inhibitory tuning equivalence in a cortical network.Nature neuroscience · 2024Article
- Coordinated head direction representations in mouse anterodorsal thalamic nucleus and retrosplenial cortex.eLife · 2024Article
- Coregistration of heading to visual cues in retrosplenial cortex.Nature communications · 2023Article
- Local Microcircuitry of PaS Shows Distinct and Common Features of Excitatory and Inhibitory Connectivity.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Spatially structured inhibition defined by polarized parvalbumin interneuron axons promotes head direction tuning.Science advances · 2021Article
- Neuron-Oligodendrocyte Communication in Myelination of Cortical GABAergic Cells.Life (Basel, Switzerland) · 2021Review
- Molecular Characterization of Superficial Layers of the Presubiculum During Development.Frontiers in neuroanatomy · 2021Article
- A gravity-based three-dimensional compass in the mouse brain.Nature communications · 2020Article
- The head direction cell network: attractor dynamics, integration within the navigation system, and three-dimensional properties.Current opinion in neurobiology · 2020Review
- Burst Firing and Spatial Coding in Subicular Principal Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Multiple Patterns of Axonal Collateralization of Single Layer III Neurons of the Rat Presubiculum.Frontiers in neural circuits · 2019Article
- Considering the Evidence for Anterior and Laterodorsal Thalamic Nuclei as Higher Order Relays to Cortex.Frontiers in molecular neuroscience · 2019Review
- Anterior Thalamic Excitation and Feedforward Inhibition of Presubicular Neurons Projecting to Medial Entorhinal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Testing the Efficacy of Single-Cell Stimulation in Biasing Presubicular Head Direction Activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Orientation in space is represented in specialized brain circuits. Persistent head direction signals are transmitted from anterior thalamus to the presubiculum, but the identity of the presubicular target neurons, their connectivity and function in local microcircuits are unknown. Here, we examine how thalamic afferents recruit presubicular principal neurons and Martinotti interneurons, and the ensuing synaptic interactions between these cells. Pyramidal neuron activation of Martinotti cells in superficial layers is strongly facilitating such that high-frequency head directional stimulation efficiently unmutes synaptic excitation. Martinotti-cell feedback plays a dual role: precisely timed spikes may not inhibit the firing of in-tune head direction cells, while exerting lateral inhibition. Autonomous attractor dynamics emerge from a modelled network implementing wiring motifs and timing sensitive synaptic interactions in the pyramidal-Martinotti-cell feedback loop. This inhibitory microcircuit is therefore tuned to refine and maintain head direction information in the presubiculum.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.