Evidence map›Paper›PMID 28726630›Full record

ArticleeLife2017

Dissection of specific binding of HIV-1 Gag to the 'packaging signal' in viral RNA.

Mauricio Comas-Garcia, Siddhartha Ak Datta, Laura Baker, Rajat Varma, Prabhakar R Gudla, Alan Rein

Open access · goldAbstract read
In one paragraph

Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 60 citations in OpenAlex.

  1. Article
  2. The biased adenosine-rich content of the HIV-1 genome serves as a molecular signature that facilitates efficient packaging.Proceedings of the National Academy of Sciences of the United States of America · 2026
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  15. 5'-Cap sequestration is an essential determinant of HIV-1 genome packaging.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  16. Review
  17. RNA Binding Properties of the Ty1 LTR-Retrotransposon Gag Protein.International journal of molecular sciences · 2021
    Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Mauricio Comas-GarciaHIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute, Frederick, United States.ORCID 0000-0002-7733-5138
Siddhartha Ak DattaHIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute, Frederick, United States.
Laura BakerHIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute, Frederick, United States.
Rajat VarmaXencor Inc., Monrovia, United States.
Prabhakar R GudlaOptical Microscopy and Analysis Laboratory, Cancer Research Technology Program, Leidos Biomedical Research, Inc., Frederick, United States.
Alan ReinHIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute, Frederick, United States.ORCID 0000-0002-8273-546X
National Cancer Institute · USLeidos (United States) · USXencor (United States) · US

Funding

Retrovirus Assembly and MaturationZIABC010511 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI REIN, ALAN · 2009 to 2025
$9.4M
NCI NIH HHS HHSN261200800001E
6 · The paper itself

Abstract

Selective packaging of HIV-1 genomic RNA (gRNA) requires the presence of a

Indexed as

Virus Assemblygag Gene Products, Human Immunodeficiency VirusHIV-1Protein BindingRNA, ViralSpectrometry, Fluorescencegag Gene Products, Human Immunodeficiency VirusRNA, ViralbiophysicsHIVinfectious diseasemicrobiologyprotein-RNA interactionretrovirusRNAstructural biologyvirusvirus assembly

Identifiers

PMID28726630
PMCPMC5531834
OpenAlexW2738591291

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.