ArticleEmerging infectious diseases2017
Molecular Characterization of Corynebacterium diphtheriae Outbreak Isolates, South Africa, March-June 2015.
Article in Emerging infectious diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Evolution and rise of antimicrobial resistance in key public health bacteria within and across the One Health sectors.Future microbiology · 2026Review
- Serological evaluation of immunity againstHuman vaccines & immunotherapeutics · 2025Article
- Corynebacterium diphtheriae Infections, South Africa, 2015-2023.Emerging infectious diseases · 2025Article
- From neglect to necessity: The case for routine work-up of nontoxigenicAfrican journal of laboratory medicine · 2025Article
- Non-toxigenicSouthern African journal of infectious diseases · 2024Article
- Genomic characterization of cocirculatingMicrobial genomics · 2023Article
- Genomic Epidemiology of Corynebacterium diphtheriae in New Caledonia.Microbiology spectrum · 2023Article
- Genomic Epidemiology and Strain Taxonomy ofJournal of clinical microbiology · 2021Article
- Whole genome sequence of a non-toxigenic Corynebacterium diphtheriae strain from a hospital in southeastern China.BMC genomic data · 2021Article
- Divergent evolution of Corynebacterium diphtheriae in India: An update from National Diphtheria Surveillance network.PloS one · 2021Article
- Genomic epidemiology of nontoxigenicMicrobial genomics · 2020Article
- Detection and Characterization of Diphtheria Toxin Gene-BearingJournal of clinical microbiology · 2020Article
- Whole-Genome Sequencing of Corynebacterium diphtheriae Isolates Recovered from an Inner-City Population Demonstrates the Predominance of a Single Molecular Strain.Journal of clinical microbiology · 2020Article
- Phenotypic and Genotypic Correlates of Penicillin Susceptibility in Nontoxigenic Corynebacterium diphtheriae, British Columbia, Canada, 2015-2018.Emerging infectious diseases · 2020Article
- Whole Genome Sequencing for Surveillance of Diphtheria in Low Incidence Settings.Frontiers in public health · 2019Review
- Whole genome sequencing suggests transmission ofEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2019Article
- Article
- A SNP-based phylogenetic analysis of Corynebacterium diphtheriae in Malaysia.BMC research notes · 2018Article
- Distinct Genomic Features Characterize Two Clades ofFrontiers in microbiology · 2018Article
- Diphtheritic myocarditis: a case report, with toxinmediated complications and multi-organ involvement.Cardiovascular journal of AfricaArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In 2015, a cluster of respiratory diphtheria cases was reported from KwaZulu-Natal Province in South Africa. By using whole-genome analysis, we characterized 21 Corynebacterium diphtheriae isolates collected from 20 patients and contacts during the outbreak (1 patient was infected with 2 variants of C. diphtheriae). In addition, we included 1 cutaneous isolate, 2 endocarditis isolates, and 2 archived clinical isolates (ca. 1980) for comparison. Two novel lineages were identified, namely, toxigenic sequence type (ST) ST-378 (n = 17) and nontoxigenic ST-395 (n = 3). One archived isolate and the cutaneous isolate were ST-395, suggesting ongoing circulation of this lineage for >30 years. The absence of preexisting molecular sequence data limits drawing conclusions pertaining to the origin of these strains; however, these findings provide baseline genotypic data for future cases and outbreaks. Neither ST has been reported in any other country; this ST appears to be endemic only in South Africa.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.