ArticleEmerging infectious diseases2017
Clinical Laboratory Values as Early Indicators of Ebola Virus Infection in Nonhuman Primates.
Article in Emerging infectious diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- C-reactive protein and association with disease severity in hospitalized adult patients with Lassa fever in Nigeria.IJID regions · 2025Article
- Limited Benefit of Postexposure Prophylaxis With VSV-EBOV in Ebola Virus-Infected Rhesus Macaques.The Journal of infectious diseases · 2023Article
- Article
- Remdesivir is efficacious in rhesus monkeys exposed to aerosolized Ebola virus.Scientific reports · 2021Article
- Intensive Care Unit-Like Care of Nonhuman Primates with Ebola Virus Disease.The Journal of infectious diseases · 2021Article
- Transcriptomic Analysis Reveals Host miRNAs Correlated with Immune Gene Dysregulation during Fatal Disease Progression in the Ebola Virus Cynomolgus Macaque Disease Model.Microorganisms · 2021Article
- Development of a Well-Characterized Rhesus Macaque Model of Ebola Virus Disease for Support of Product Development.Microorganisms · 2021Article
- Antiviral Innate Responses Induced by VSV-EBOV Vaccination Contribute to Rapid Protection.mBio · 2019Article
- Characterization of the plasma proteome of nonhuman primates during Ebola virus disease or melioidosis: a host response comparison.Clinical proteomics · 2019Article
- Virulence of Marburg Virus Angola Compared to Mt. Elgon (Musoke) in Macaques: A Pooled Survival Analysis.Viruses · 2018Article
- Ebola Virus Causes Intestinal Tract Architectural Disruption and Bacterial Invasion in Non-Human Primates.Viruses · 2018Article
Corrections and comments
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Ebola virus (EBOV) outbreak in West Africa during 2013-2016 demonstrated the need to improve Ebola virus disease (EVD) diagnostics and standards of care. This retrospective study compared laboratory values and clinical features of 3 nonhuman primate models of lethal EVD to assess associations with improved survival time. In addition, the study identified laboratory values useful as predictors of survival, surrogates for EBOV viral loads, and triggers for initiation of therapeutic interventions in these nonhuman primate models. Furthermore, the data support that, in nonhuman primates, the Makona strain of EBOV may be less virulent than the Kikwit strain of EBOV. The applicability of these findings as potential diagnostic and management tools for EVD in humans warrants further investigation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.