Evidence map›Paper›PMID 28726529›Full record

ArticleRenal failure2017

Factors associated with the elevated percentage of CD4CD69 T cells in maintained hemodialysis patients.

Rongyi Chen, Fangfang Xiang, Jiachang Hu, Xuesen Cao, Xiao Tan, Ping Jia, Ting Zhang, Nana Song, Yi Fang, Xiaoqiang Ding and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Renal failure, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Rongyi Chena Division of Nephrology , Zhongshan Hospital, Shanghai Medical College, Fudan University , Shanghai , China.
Fangfang Xianga Division of Nephrology , Zhongshan Hospital, Shanghai Medical College, Fudan University , Shanghai , China.
Jiachang Hua Division of Nephrology , Zhongshan Hospital, Shanghai Medical College, Fudan University , Shanghai , China.
Xuesen Caoa Division of Nephrology , Zhongshan Hospital, Shanghai Medical College, Fudan University , Shanghai , China.
Xiao Tana Division of Nephrology , Zhongshan Hospital, Shanghai Medical College, Fudan University , Shanghai , China.
Ping Jiaa Division of Nephrology , Zhongshan Hospital, Shanghai Medical College, Fudan University , Shanghai , China.
Ting Zhanga Division of Nephrology , Zhongshan Hospital, Shanghai Medical College, Fudan University , Shanghai , China.
Nana Songa Division of Nephrology , Zhongshan Hospital, Shanghai Medical College, Fudan University , Shanghai , China.
Yi Fanga Division of Nephrology , Zhongshan Hospital, Shanghai Medical College, Fudan University , Shanghai , China.
Xiaoqiang Dinga Division of Nephrology , Zhongshan Hospital, Shanghai Medical College, Fudan University , Shanghai , China.
Jianzhou Zoua Division of Nephrology , Zhongshan Hospital, Shanghai Medical College, Fudan University , Shanghai , China.
Shanghai Blood Center · CNShanghai Medical College of Fudan University · CNShanghai Institute of Hematology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCD4 T-cell abnormality, influencing the outcome of the maintained hemodialysis (MHD), is common in patients on dialysis. We try to find out factors associated with the activated CD4 T cells, CD4CD69 T cells, to improve the dialysis quality.

methodsA cross-sectional study was conducted to evaluate the change of CD4CD69 in MHD patients and healthy controls in our hospital from September 2015 to May 2016. A total of 164 MHD patients and 24 healthy controls were included according to the criteria. Univariate and multivariate logistic regression models after correlation analysis were executed to discover the related factors of CD4CD69 T-cell posterior to the division of the CD4CD69 T cell according to its median.

resultsThe lymphocytes were lower, but the percentage of CD4CD69 T cells was higher in MHD patients compared with healthy controls, even after the propensity score matching based on age and sex. The percentage of CD4 T cells showed no significant difference between the two groups. Further multivariate logistic regression models revealed that CD4CD69 T cell was independently associated with serum total protein (OR 95%CI: 0.830[0.696, 0.990], p = .038), transferrin (OR 95%CI: 3.072[1.131, 8.342], p = .028) and magnesium (OR 95%CI: 16.960[1.030, 279.275], p = .048).

conclusionThe percentage of CD4CD69 T cells, activated CD4 T cells, elevated in hemodialysis patients despite the decrease in lymphocytes. The elevated CD4CD69 T cells were independently associated with serum total protein negatively, but transferrin and magnesium positively. Strengthening nutrition, reducing the concentration of transferrin and magnesium might be beneficial to reduce the activation of CD4 T cells and improve the outcome of MHD patients.

Indexed as

AgedAntigens, CDAntigens, Differentiation, T-LymphocyteCD4 Lymphocyte CountCD4-Positive T-LymphocytesCD69 AntigensCross-Sectional StudiesFemaleHumansKidney Failure, ChronicLectins, C-TypeLymphocyte ActivationMagnesiumMaleMiddle AgedNutritional StatusAntigens, CDAntigens, Differentiation, T-LymphocyteCD69 AntigensLectins, C-TypeMagnesiumTransferrinCD4 T cellCD69hemodialysismagnesiumtotal proteintransferrin

Identifiers

PMID28726529
PMCPMC6014306
OpenAlexW2736752337

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.