Evidence map›Paper›PMID 28726424›Full record

ArticleMolecular pharmaceutics2017

Self-encapsulating Poly(lactic-co-glycolic acid) (PLGA) Microspheres for Intranasal Vaccine Delivery.

Brittany A Bailey, Kashappa-Goud H Desai, Lukasz J Ochyl, Susan M Ciotti, James J Moon, Steven P Schwendeman

Abstract read
In one paragraph

Article in Molecular pharmaceutics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Exploring the effects of excipients on complex coacervation.Journal of colloid and interface science · 2025
    Article
  2. Article
  3. Poly(lactic-ACS biomaterials science & engineering · 2025
    Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
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  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Brittany A BaileyDepartment of Pharmaceutical Sciences and the Biointerfaces Institute, University of Michigan , Ann Arbor, Michigan 48109, United States.
Kashappa-Goud H DesaiDepartment of Pharmaceutical Sciences and the Biointerfaces Institute, University of Michigan , Ann Arbor, Michigan 48109, United States.
Lukasz J OchylDepartment of Pharmaceutical Sciences and the Biointerfaces Institute, University of Michigan , Ann Arbor, Michigan 48109, United States.
Susan M CiottiNanoBio Corporation , 2311 Green Road, Ann Arbor, Michigan 48105, United States.
James J MoonDepartment of Pharmaceutical Sciences and the Biointerfaces Institute, University of Michigan , Ann Arbor, Michigan 48109, United States.
Steven P SchwendemanDepartment of Pharmaceutical Sciences and the Biointerfaces Institute, University of Michigan , Ann Arbor, Michigan 48109, United States.ORCID 0000-0003-3470-624X

Funding

INTERDEPARTMENTAL TRAINING IN PHARMACOLOGICAL SCIENCEST32GM007767 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ISOM, LORI L. · 1985 to 2019
$10.2M
Elicitation of mucosal immune responses against HIVR01AI127070 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MOON, JAMES J. · 2016 to 2020
$2.3M
Nanomaterials for eliciting anti-tumor T-cells-Diversity SupplementR01CA210273 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MOON, JAMES J. · 2017 to 2021
$2.2M
Tuning Biomaterials-immune cell interactions for treatment of glioblastoma multiformeR01EB022563 · NIBIB · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MOON, JAMES J. · 2016 to 2019
$1.7M
Controlled Photo-Release of Nitric Oxide for Antimicrobial Inhalation TherapyR21EB024038 · NIBIB · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SCHWENDEMAN, STEVEN P. · 2017 to 2018
$427k
Self-microencapsulation in polymer delivery systems without organic solventsR21EB008873 · NIBIB · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SCHWENDEMAN, STEVEN P. · 2009 to 2010
$416k
NCI NIH HHS R01 CA210273NIAID NIH HHS R01 AI127070NIBIB NIH HHS R01 EB022563NIBIB NIH HHS R21 EB008873NIBIB NIH HHS R21 EB024038NIGMS NIH HHS T32 GM007767
6 · The paper itself

Abstract

Herein we describe a formulation of self-encapsulating poly(lactic-co-glycolic acid) (PLGA) microspheres for vaccine delivery. Self-healing encapsulation is a novel encapsulation method developed by our group that enables the aqueous loading of large molecules into premade PLGA microspheres. Calcium phosphate (CaHPO

Indexed as

MicrospheresAnimalsCalcium PhosphatesCholera ToxinChromatography, High Pressure LiquidDrug Delivery SystemsEnzyme-Linked Immunosorbent AssayFemaleLactic AcidMiceMice, Inbred C57BLMicroscopy, Electron, ScanningOvalbuminPolyglycolic AcidPolylactic Acid-Polyglycolic Acid CopolymerVaccinescalcium phosphateCalcium PhosphatesCholera ToxinLactic AcidOvalbuminPolyglycolic AcidPolylactic Acid-Polyglycolic Acid CopolymerVaccinescalcium phosphate adjuvantencapsulationintranasal immunizationpoly(lactic-co-glycolic acid)polymer microspheresvaccine delivery

Identifiers

PMID28726424
PMCPMC5642922

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.