Evidence map›Paper›PMID 28726088›Full record

ArticleDoklady. Biochemistry and biophysics2017

Involvement of two-pore channels in hydrogen peroxide-induced increase in the level of calcium ions in the cytoplasm of human umbilical vein endothelial cells.

P V Avdonin, A D Nadeev, E B Tsitrin, A A Tsitrina, P P Avdonin, G Yu Mironova, I L Zharkikh, N V Goncharov

Abstract read
PubMed Publisher
In one paragraph

Article in Doklady. Biochemistry and biophysics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Reactive Oxygen Species and Endothelial CaInternational journal of molecular sciences · 2021
    Review
  2. Article
  3. Markers of Endothelial Cells in Normal and Pathological Conditions.Biochemistry (Moscow) Supplement. Series A, Membrane and cell biology · 2020
    Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

P V AvdoninKoltzov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, 119334, Russia. pvavdonin@yandex.ru.
A D NadeevInstitute of Biophysics, Pushchino Branch, Russian Academy of Sciences, Pushchino, Moscow oblast, 142290, Russia.
E B TsitrinKoltzov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, 119334, Russia.
A A TsitrinaKoltzov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, 119334, Russia.
P P AvdoninKoltzov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, 119334, Russia.
G Yu MironovaKoltzov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, 119334, Russia.
I L ZharkikhResearch Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, 125315, Russia.
N V GoncharovSechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, 194223, Russia.
Koltzov Institute of Developmental Biology · RUInstitute of Evolutionary Physiology and Biochemistry · RUResearch Institute of General Pathology and Pathophysiology, the Russian Academy of Medical Sciences · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hydrogen peroxide at concentrations below cytotoxic ones causes an increase in the cytoplasmic calcium concentration in human umbilical vein endothelial cells as a result of calcium release from intracellular stores. Two-pore calcium channel blocker trans-NED19 partially suppresses the increase in the level of calcium ions in the cells in response to the addition of hydrogen peroxide. The staining of endothelial cells with the fluorescent stereoisomer cis-NED19 and LysoTracker confirmed the localization of two-pore calcium channels in lysosomes and endolysosomal vesicles.

Indexed as

CalciumCalcium Channel BlockersCalcium ChannelsCarbolinesCytoplasmHumansHuman Umbilical Vein Endothelial CellsHydrogen PeroxidePiperazinesPorosity1-(3-((4-(2-fluorophenyl)piperazin-1-yl)methyl)-4-methoxyphenyl)-2,3,4,9-tetrahydro-1H-pyrido(3,4-b)indole-3-carboxylic acidCalciumCalcium Channel BlockersCalcium ChannelsCarbolinesHydrogen PeroxidePiperazines

Identifiers

PMID28726088
OpenAlexW2738359861

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.