ReviewCurrent psychiatry reports2017
Valproic Acid in Women and Girls of Childbearing Age.
Review in Current psychiatry reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- The relationships between obesity and epilepsy: A systematic review with meta-analysis.PloS one · 2024Pooled it
- Evaluation of prescribing patterns of sodium valproate in neurological disease patients: a quasi-experimental pretest-posttest design study.BMC health services research · 2025Trial
- Genetic risk, antiseizure medications, and lifestyle factors in epilepsy-associated obesity and overweight.International journal of obesity (2005) · 2026Article
- Co-Occurring Bipolar and Substance Use Disorders: A Review of Impacts, Biopsychosocial Mechanisms, Assessment, and Treatment.Focus (American Psychiatric Publishing) · 2025Review
- Gestational Fisetin Exerts Neuroprotection by Regulating Mitochondria-Directed Canonical Wnt Signaling, BBB Integrity, and Apoptosis in Prenatal VPA-Induced Rodent Model of Autism.Molecular neurobiology · 2024Article
- Specific Birth Defects Following Antiseizure Medications Used By Pregnant Women With Epilepsy.Neurology. Clinical practice · 2024Article
- Ethnic Aspects of Valproic Acid P-Oxidation.Biomedicines · 2024Review
- Study of Burden in Polycystic Ovary Syndrome at Global, Regional, and National Levels from 1990 to 2019.Healthcare (Basel, Switzerland) · 2023Article
- Characteristics and Challenges of Epilepsy in Children with Cerebral Palsy-A Population-Based Study.Journal of clinical medicine · 2023Article
- Borderline Personality Disorder "Discouraged Type": A Case Report.Medicina (Kaunas, Lithuania) · 2022Article
- Twice Daily Prazosin and Valproic Acid in the Treatment of Flashbacks in PTSD.Case reports in psychiatry · 2022Article
- Long-term use of antidepressants, mood stabilizers, and antipsychotics in pediatric patients with a focus on appropriate deprescribing.The mental health clinician · 2021Article
- Sex differences in pharmacological treatment of major depressive disorder: results from the AMSP pharmacovigilance program from 2001 to 2017.Journal of neural transmission (Vienna, Austria : 1996) · 2021Article
- Post-stroke Delivery of Valproic Acid Promotes Functional Recovery and Differentially Modifies Responses of Peri-Infarct Microglia.Frontiers in molecular neuroscience · 2021Article
- Research Progress on the Effect of Epilepsy and Antiseizure Medications on PCOS Through HPO Axis.Frontiers in endocrinology · 2021Review
- Why Do Psychiatrists Still Prescribe Valproate to Women of Childbearing Potential?Frontiers in psychiatry · 2020Article
- Photosensitive Epilepsy and Polycystic Ovary Syndrome as Manifestations of MERRF.Case reports in neurological medicine · 2020Article
- Early Behavioral Alterations and Increased Expression of Endogenous Retroviruses Are Inherited Across Generations in Mice Prenatally Exposed to Valproic Acid.Molecular neurobiology · 2019Article
- Out of sight, out of mind? Germ cells and the potential impacts of epigenomic drugs.F1000Research · 2018Review
- Pharmacological inhibition of EZH2 disrupts the female germline epigenome.Clinical epigenetics · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of reviewThe aim of this paper is to evaluate recent literature on valproic acid (VPA) in women and girls of childbearing age and to emphasize new findings. RECENT
findingsRecent research confirms VPAs teratogenicity and risk of hormone disruption. VPA exposure in utero increases the risk for a variety of major congenital malformations (MCMs), reduced IQ and behavioral problems. In girls and women, VPA increases the risk of hormone abnormalities, obesity, and polycystic ovarian syndrome (PCOS). Despite guidelines recommending caution, VPA use continues to be prescribed to reproductive-aged women and girls. Despite significant and well-documented risk, adherence to guidelines in VPA use in reproductive-aged girls and women remains low.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.