Evidence map›Paper›PMID 28726022›Full record

Trial reportAnnals of biomedical engineering2017

Quantification of Hand Motor Symptoms in Parkinson's Disease: A Proof-of-Principle Study Using Inertial and Force Sensors.

Josien C van den Noort, Rens Verhagen, Kees J van Dijk, Peter H Veltink, Michelle C P M Vos, Rob M A de Bie, Lo J Bour, Ciska T Heida

Open access · hybridAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Annals of biomedical engineering, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Review
  5. Article
  6. Rigidity in Parkinson's Disease: The Objective Effect of Levodopa.Movement disorders : official journal of the Movement Disorder Society · 2025
    Article
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  9. Review
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  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Josien C van den NoortBiomedical Signals and Systems Group, MIRA Research Institute for Biomedical Technology and Technical Medicine, University of Twente, P.O. Box 217, 7500 AE, Enschede, The Netherlands. j.vandennoort@vumc.nl.
Rens VerhagenDepartment of Neurology and Clinical Neurophysiology, Academic Medical Center, Amsterdam, The Netherlands.
Kees J van DijkBiomedical Signals and Systems Group, MIRA Research Institute for Biomedical Technology and Technical Medicine, University of Twente, P.O. Box 217, 7500 AE, Enschede, The Netherlands.
Peter H VeltinkBiomedical Signals and Systems Group, MIRA Research Institute for Biomedical Technology and Technical Medicine, University of Twente, P.O. Box 217, 7500 AE, Enschede, The Netherlands.
Michelle C P M VosBiomedical Signals and Systems Group, MIRA Research Institute for Biomedical Technology and Technical Medicine, University of Twente, P.O. Box 217, 7500 AE, Enschede, The Netherlands.
Rob M A de BieDepartment of Neurology and Clinical Neurophysiology, Academic Medical Center, Amsterdam, The Netherlands.
Lo J BourDepartment of Neurology and Clinical Neurophysiology, Academic Medical Center, Amsterdam, The Netherlands.
Ciska T HeidaBiomedical Signals and Systems Group, MIRA Research Institute for Biomedical Technology and Technical Medicine, University of Twente, P.O. Box 217, 7500 AE, Enschede, The Netherlands.
University of Twente · NLAcademic Medical Center · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This proof-of-principle study describes the methodology and explores and demonstrates the applicability of a system, existing of miniature inertial sensors on the hand and a separate force sensor, to objectively quantify hand motor symptoms in patients with Parkinson's disease (PD) in a clinical setting (off- and on-medication condition). Four PD patients were measured in off- and on- dopaminergic medication condition. Finger tapping, rapid hand opening/closing, hand pro/supination, tremor during rest, mental task and kinetic task, and wrist rigidity movements were measured with the system (called the PowerGlove). To demonstrate applicability, various outcome parameters of measured hand motor symptoms of the patients in off- vs. on-medication condition are presented. The methodology described and results presented show applicability of the PowerGlove in a clinical research setting, to objectively quantify hand bradykinesia, tremor and rigidity in PD patients, using a single system. The PowerGlove measured a difference in off- vs. on-medication condition in all tasks in the presented patients with most of its outcome parameters. Further study into the validity and reliability of the outcome parameters is required in a larger cohort of patients, to arrive at an optimal set of parameters that can assist in clinical evaluation and decision-making.

Indexed as

FingersHand StrengthHypokinesiaParkinson DiseaseTremorAdultFemaleHumansMaleMiddle AgedProof of Concept StudyBradykinesiaFingersHandInertial sensorsMovement analysisParkinson’s diseaseRigidityTremor

Identifiers

PMID28726022
PMCPMC5622175
OpenAlexW2739205738

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.