ArticleEuropean biophysics journal : EBJ2018
Membrane phase transition during heating and cooling: molecular insight into reversible melting.
Article in European biophysics journal : EBJ, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Article
- DPPC Membrane Under Lateral Compression and Stretching to Extreme Limits: Phase Transitions and Rupture.Membranes · 2025Article
- Enhanced cell survival in prepubertal testicular tissue cryopreserved with membrane lipids and antioxidants rich cryopreservation medium.Cell and tissue research · 2025Article
- Liposome-based Freezing Medium Improves the Outcome of Mouse Prepubertal Testicular Tissue Cryopreservation.Reproductive sciences (Thousand Oaks, Calif.) · 2024Article
- SMARTINI3 parametrization of multi-scale membrane models via unsupervised learning methods.Scientific reports · 2024Article
- CGCompiler: Automated Coarse-Grained Molecule Parametrization via Noise-Resistant Mixed-Variable Optimization.Journal of chemical theory and computation · 2023Article
- Elucidating lipid conformations in the ripple phase: Machine learning reveals four lipid populations.Biophysical journal · 2023Article
- Photothermal scaffolds/surfaces for regulation of cell behaviors.Bioactive materials · 2022Review
- Native-like membrane models of E. coli polar lipid extract shed light on the importance of lipid composition complexity.BMC biology · 2021Article
- Tocopheryl Succinate-Induced Structural Changes in DPPC Liposomes: DSC and ANS Fluorescence Studies.Molecules (Basel, Switzerland) · 2020Article
- Highly cooperative fluorescence switching of self-assembled squaraine dye at tunable threshold temperatures using thermosensitive nanovesicles for optical sensing and imaging.Scientific reports · 2019Article
- Coupling of Membrane Nanodomain Formation and Enhanced Electroporation near Phase Transition.Biophysical journal · 2019Article
- Temperature- and rigidity-mediated rapid transport of lipid nanovesicles in hydrogels.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
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Authors and funding
2 authors.
Funding
Abstract
With increasing temperature, lipid bilayers undergo a gel-fluid phase transition, which plays an essential role in many physiological phenomena. In the present work, this first-order phase transition was investigated for variable heating and cooling rates for a dipalmitoylphosphatidylcholine (DPPC) lipid bilayer by means of atomistic molecular dynamics simulations. Alternative methods to track the melting temperature [Formula: see text] are compared. The resulting [Formula: see text] is shown to be independent of the scan rate for small heating rates (0.05-0.3 K/ns) implying reversible melting, and increases for larger heating (0.3-4 K/ns) or cooling rates (2-0.1 K/ns). The reported dependency of the melting temperature on the heating rate is in perfect agreement with a two-state kinetic rate model as suggested previously. Expansion and shrinkage, as well as the dynamics of melting seeds is described. The simulations further exhibit a relative shift between melting seeds in opposing membrane leaflets as predicted from continuum elastic theory.
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