Evidence map›Paper›PMID 28725972›Full record

ArticleGlycoconjugate journal2017

The versatility of N-alkyl-methoxyamine bi-functional linkers for the preparation of glycoconjugates.

Stefan Munneke, Emma M Dangerfield, Bridget L Stocker, Mattie S M Timmer

Abstract read
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In one paragraph

Article in Glycoconjugate journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Synthesis and Application of Methyl N,O-Hydroxylamine Muramyl Peptides.Chembiochem : a European journal of chemical biology · 2019
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Stefan MunnekeSchool of Chemical and Physical Sciences, PO Box 600, Wellington, New Zealand.
Emma M DangerfieldSchool of Chemical and Physical Sciences, PO Box 600, Wellington, New Zealand.
Bridget L StockerSchool of Chemical and Physical Sciences, PO Box 600, Wellington, New Zealand. bridget.stocker@vuw.ac.nz.
Mattie S M TimmerSchool of Chemical and Physical Sciences, PO Box 600, Wellington, New Zealand. mattie.timmer@vuw.ac.nz.ORCID 0000-0001-7884-0729
Statistics New Zealand · NZVictoria University of Wellington · NZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The application of N-glycosyl-N-alkyl-methoxyamine bi-functional linkers for the synthesis of a variety of glycoconjugates is described. The linker contains a specific functional group, such as an amine, azide, thiol, or carboxylic acid, which can be used for conjugation methodologies that include amide ligation, sulfonylation, copper-mediated Huisgen cycloaddition or thiol-maleimide coupling. In this way, glycoconjugates equipped with biotin, a fluorescent reporter, or a protein were efficiently synthesised, thus demonstrating the versatility of this type of oxyamine linker for the construction of glycoconjugate probes.

Indexed as

AzidesBiotinCarbohydrate ConformationCarboxylic AcidsClick ChemistryCycloaddition ReactionFluorescent DyesGlycoconjugatesHumansHydroxylaminesSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationSulfhydryl CompoundsAzidesBiotinCarboxylic AcidsFluorescent DyesGlycoconjugatesHydroxylaminesmethoxyamineSulfhydryl CompoundsGlycoconjugateLinkerOligosaccharideOxyamineProbe

Identifiers

PMID28725972
OpenAlexW2737223265

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.