ArticleNPJ microgravity2016
Treadmill exercise within lower-body negative pressure attenuates simulated spaceflight-induced reductions of balance abilities in men but not women.
Article in NPJ microgravity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 21 citations in OpenAlex.
- Women in space: A review of known physiological adaptations and health perspectives.Experimental physiology · 2026Review
- A systematic review identifying fitness metrics indicative of simulated astronaut extravehicular activity task performance.NPJ microgravity · 2026Article
- Blood flow restriction training in microgravity: a review of multisystem physiological benefits and implementation challenges for long-duration space missions.NPJ microgravity · 2025Review
- A Pilot Study to Evaluate the Relationships between Supine Proprioception Assessments and Upright Functional Mobility.Brain sciences · 2024Article
- Effects of intermittent seating upright, lower body negative pressure, and exercise on functional tasks performance after head-down tilt bed rest.Frontiers in physiology · 2024Article
- Comprehensive assessment of physiological responses in women during the ESA dry immersion VIVALDI microgravity simulation.Nature communications · 2023Article
- Cognition in zero gravity: Effects of non-terrestrial gravity on human behaviour.Quarterly journal of experimental psychology (2006) · 2023Article
- Cognitive and balance functions of astronauts after spaceflight are comparable to those of individuals with bilateral vestibulopathy.Frontiers in neurology · 2023Article
- Tandem Walk in Simulated Martian Gravity and Visual Environment.Brain sciences · 2022Article
- Modeling individual differences in cardiovascular response to gravitational stress using a sensitivity analysis.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Article
- Developing Proprioceptive Countermeasures to Mitigate Postural and Locomotor Control Deficits After Long-Duration Spaceflight.Frontiers in systems neuroscience · 2021Review
- Physiological and Functional Alterations after Spaceflight and Bed Rest.Medicine and science in sports and exercise · 2018Article
- Vestibular brain changes within 70 days of head down bed rest.Human brain mapping · 2018Article
- Change of cortical foot activation following 70 days of head-down bed rest.Journal of neurophysiology · 2018Article
- High Intensity Jump Exercise Preserves Posture Control, Gait, and Functional Mobility During 60 Days of Bed-Rest: An RCT Including 90 Days of Follow-Up.Frontiers in physiology · 2018Article
- Comparison of Autonomic Control of Blood Pressure During Standing and Artificial Gravity Induced via Short-Arm Human Centrifuge.Frontiers in physiology · 2018Article
- Adaptation to microgravity, deconditioning, and countermeasures.The journal of physiological sciences : JPS · 2017Review
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spaceflight causes sensorimotor adaptations that result in balance deficiencies on return to a gravitational environment. Treadmill exercise within lower-body negative pressure (LBNP) helps protect physiological function during microgravity as simulated by bed rest. Therefore, we hypothesized that treadmill exercise within LBNP would prevent balance losses in both male and female identical twins during 30 days of 6° head-down tilt bed rest. Fifteen (seven female and eight male) identical twin sets participated in this simulation of microgravity. Within each twin pair, one twin was randomly assigned to an exercise group that performed 40 min of supine treadmill exercise within LBNP set to generate 1.0-1.2 body weight, followed by 5 min of static feet-supported LBNP, 6 days per week. Their identical sibling was assigned to a non-exercise control group with all other bed rest conditions equivalent. Before and immediately after bed rest, subjects completed standing and walking rail balance tests with eyes open and eyes closed. In control subjects, standing rail balance times (men: -42%, women: -40%), rail walk distances (men: -44%, women: -32%) and rail walk times (men: -34%, women: -31%) significantly decreased after bed rest. Compared with controls, treadmill exercise within LBNP significantly attenuated losses of standing rail balance time by 63% in men, but the 41% attenuation in women was not significant. Treadmill exercise within LBNP did not affect rail walk abilities in men or women. Treadmill exercise within LBNP during simulated spaceflight attenuates loss of balance control in men but not in women.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.