ReviewNPJ microgravity2015
Microgravity protein crystallization.
Review in NPJ microgravity, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed.
- Electroporation outcomes in human Jurkat cells are affected by exposure to simulated microgravity.Research square · 2026Article
- Crystallization for Manufacturing in Microgravity; Are We There Yet?Crystal growth & design · 2026Article
- Beyond Earth: Recent Advancements in Microgravity Biomedical and Genetic Research in Saudi Arabia.International journal of molecular sciences · 2026Review
- Emerging Chemical and Biological Materials Technologies in the Extraplanetary Environment.Nano-micro letters · 2026Review
- The hierarchical stratum response system of organism to microgravity during spaceflight.Military Medical Research · 2026Review
- Gluebodies Offer a Route To Improve Crystal Reliability and Diversity through Transferable Nanobody Mutations That Introduce Constitutive Close Contacts.ACS central science · 2025Article
- Microgravity-Assisted Exploration of the Conformational Space of Amyloid β Affected by Tottori-Type Familial Mutation D7N.ACS chemical neuroscience · 2025Article
- Exploring the potential of a bioassembler for protein crystallization in space.NPJ microgravity · 2025Article
- The first report of structural analysis of a nucleic acid using crystals grown in space.Acta crystallographica. Section F, Structural biology communications · 2025Article
- Impact of simulated microgravity in short-term evolution of an RNA bacteriophage.Frontiers in microbiology · 2025Article
- Random mutagenesis and disulfide bond formation improved thermostability in microbial transglutaminase.Applied microbiology and biotechnology · 2024Article
- Microgravity-like Crystallization of Paramagnetic Species in Strong Magnetic Fields.International journal of molecular sciences · 2024Article
- Enhanced assembly of bacteriophage T7 produced in cell-free reactions under simulated microgravity.NPJ microgravity · 2024Article
- Public-private partnerships in fostering outer space innovations.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Equilibration of precipitants in a counter-diffusion apparatus for protein crystallization.Journal of applied crystallography · 2023Article
- Polymer-based microfluidic device for on-chip counter-diffusive crystallization andLab on a chip · 2023Article
- Microgravity environment grown crystal structure information based engineering of direct electron transfer type glucose dehydrogenase.Communications biology · 2022Article
- Space Medicines for Space Health.ACS medicinal chemistry letters · 2022Article
- Microgravity crystallization of perdeuterated tryptophan synthase for neutron diffraction.NPJ microgravity · 2022Article
- Biomanufacturing in low Earth orbit for regenerative medicine.Stem cell reports · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Over the past 20 years a variety of technological advances in X-ray crystallography have shortened the time required to determine the structures of large macromolecules (i.e., proteins and nucleic acids) from several years to several weeks or days. However, one of the remaining challenges is the ability to produce diffraction-quality crystals suitable for a detailed structural analysis. Although the development of automated crystallization systems combined with protein engineering (site-directed mutagenesis to enhance protein solubility and crystallization) have improved crystallization success rates, there remain hundreds of proteins that either cannot be crystallized or yield crystals of insufficient quality to support X-ray structure determination. In an attempt to address this bottleneck, an international group of scientists has explored use of a microgravity environment to crystallize macromolecules. This paper summarizes the history of this international initiative along with a description of some of the flight hardware systems and crystallization results.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.