Evidence map›Paper›PMID 28725683›Full record

ArticleNPJ Parkinson's disease2015

Why is there motor deterioration in Parkinson's disease during systemic infections-a hypothetical view.

Florian Brugger, Roberto Erro, Bettina Balint, Georg Kägi, Paolo Barone, Kailash P Bhatia

Open access · goldAbstract readEditorial
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ Parkinson's disease, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.

  1. Pooled it
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  10. Long COVID: From olfactory dysfunctions to viral Parkinsonism.World journal of otorhinolaryngology - head and neck surgery · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Florian BruggerSobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College of London, London, UK.
Roberto ErroSobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College of London, London, UK.
Bettina BalintSobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College of London, London, UK.
Georg KägiDepartment of Neurology, Kantonsspital St Gallen, St Gallen, Switzerland.
Paolo BaroneCentre of Neurodegenerative Diseases-CEMAND, University of Salerno, Salerno, Italy.
Kailash P BhatiaSobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College of London, London, UK.
Sobell House · GBKantonsspital St. Gallen · CHUniversity of Salerno · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Clinicians are well aware of the fact that patients with Parkinson's disease may significantly deteriorate following a systemic infection or, in its most severe case, may even develop an akinetic crisis. Although this phenomenon is widely observed and has a major impact on the patients' condition, the knowledge about the underlying mechanisms behind is still sparse. Possible explanations encompass changes in the pharmacodynamics of the dopaminergic drugs, altered dopamine metabolism in the brain, alterations in the dopaminergic transmission in the striatum or an enhancement of neurodegeneration due to remote effects of peripheral inflammatory processes or circulating bacterial toxins. This article provides possible explanatory concepts and may hence support formulating hypothesis for future studies in this field.

Identifiers

PMID28725683
PMCPMC5516617
OpenAlexW2594123267

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.