Evidence map›Paper›PMID 28725547›Full record

ArticleNeuroImage. Clinical2017

Spatial working memory in neurofibromatosis 1: Altered neural activity and functional connectivity.

Amira F A Ibrahim, Caroline A Montojo, Kristen M Haut, Katherine H Karlsgodt, Laura Hansen, Eliza Congdon, Tena Rosser, Robert M Bilder, Alcino J Silva, Carrie E Bearden

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage. Clinical, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Stimulus-specific influence of gender on mental-rotation-related brain activity.Cognitive, affective & behavioral neuroscience · 2025
    Article
  7. Review
  8. Article
  9. Article
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  11. Verbal learning and memory in youth with neurofibromatosis type 1 and plexiform neurofibromas: Relationships with disease severity.European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society · 2022
    Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. An executive functioning perspective in neurofibromatosis type 1: from ADHD and autism spectrum disorder to research domains.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2020
    Review
  17. Brain-wide structural and functional disruption in mice with oligodendrocyte-specificProceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 1 country.

Amira F A IbrahimDepartment of Psychology, University of Michigan, Ann Arbor, United States.
Caroline A MontojoKavli Foundation, Oxnard, United States.
Kristen M HautDepartment of Psychiatry, Rush University Medical Center, United States.
Katherine H KarlsgodtDepartment of Psychology, University of California, Los Angeles, United States; Department of Psychiatry & Biobehavioral Sciences, University of California, Los Angeles, United States.
Laura HansenDepartment of Psychiatry & Biobehavioral Sciences, University of California, Los Angeles, United States.
Eliza CongdonDepartment of Psychiatry & Biobehavioral Sciences, University of California, Los Angeles, United States.
Tena RosserDepartment of Neurology, Children's Hospital of Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, United States.
Robert M BilderDepartment of Psychology, University of California, Los Angeles, United States; Department of Psychiatry & Biobehavioral Sciences, University of California, Los Angeles, United States.
Alcino J SilvaDepartment of Psychology, University of California, Los Angeles, United States; Department of Psychiatry & Biobehavioral Sciences, University of California, Los Angeles, United States; Department of Neurobiology, University of California, Los Angeles, United States; Integrative Center for Learning and Memory, University of California, Los Angeles, United States.
Carrie E BeardenDepartment of Psychology, University of California, Los Angeles, United States; Department of Psychiatry & Biobehavioral Sciences, University of California, Los Angeles, United States; Integrative Center for Learning and Memory, University of California, Los Angeles, United States. Electronic address: CBearden@mednet.ucla.edu.
Neurobehavioral Systems · USUniversity of California, Los Angeles · USChildren's Hospital of Los Angeles · USRush University Medical Center · USThe Kavli Foundation · USUniversity of Michigan–Ann Arbor · US

Funding

UCLA Center for Translational Research in Neurodevelopment: UC-TRaNU54HD087101 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MCCRACKEN, JAMES T. · 2016 to 2020
$6.5M
Human Translational Applications Core (HTA - Core) (7 of 8)PL1MH083271 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BILDER, ROBERT M · 2007 to 2011
$5.8M
Mechanisms for Neurological Dysfunction in NF1 and Noonan SyndromeR01MH084315 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SILVA, ALCINO J. · 2008 to 2020
$5.0M
Consortium for Neuropsychiatric Phenomics-Coordinating Center (1 of 8)UL1DE019580 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BILDER, ROBERT M · 2008 to 2011
$1.9M
Neurofibromatosis Type I as a Model for Therapeutic NeuroadaptationR34MH089299 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BEARDEN, CARRIE E · 2009 to 2011
$691k
NICHD NIH HHS U54 HD087101NIDCR NIH HHS UL1 DE019580NIMH NIH HHS PL1 MH083271NIMH NIH HHS R01 MH084315NIMH NIH HHS R34 MH089299
6 · The paper itself

Abstract

backgroundNeurofibromatosis Type 1 (NF1) is a genetic disorder that disrupts central nervous system development and neuronal function. Cognitively, NF1 is characterized by difficulties with executive control and visuospatial abilities. Little is known about the neural substrates underlying these deficits. The current study utilized Blood-Oxygen-Level-Dependent (BOLD) functional MRI (fMRI) to explore the neural correlates of spatial working memory (WM) deficits in patients with NF1.

methodsBOLD images were acquired from 23 adults with NF1 (age

resultsRelative to healthy controls, participants with NF1 showed reduced recruitment of key components of WM circuitry, the left dorsolateral prefrontal cortex and right parietal cortex. In addition, healthy controls exhibited greater simultaneous deactivation between the posterior cingulate cortex (PCC) and temporal regions than NF1 patients. In contrast, NF1 patients showed greater PCC and bilateral parietal connectivity with visual cortices as well as between the PCC and the cerebellum. In NF1 participants, increased functional coupling of the PCC with frontal and parietal regions was associated with better spatial reasoning and WM performance, respectively; these relationships were not observed in controls.

conclusionsDysfunctional engagement of WM circuitry, and aberrant functional connectivity of 'task-negative' regions in NF1 patients may underlie spatial WM difficulties characteristic of the disorder.

Indexed as

AdolescentAdultBrainBrain MappingFemaleHumansMagnetic Resonance ImagingMaleMemory DisordersMemory, Short-TermMiddle AgedNeurofibromatosis 1Spatial MemoryYoung AdultfMRINF1Psychophysiological interactionSpatial abilityWorking memory

Identifiers

PMID28725547
PMCPMC5501884
OpenAlexW2731245571

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.