Evidence map›Paper›PMID 28725465›Full record

ArticleNPJ systems biology and applications2016

Network analyses based on comprehensive molecular interaction maps reveal robust control structures in yeast stress response pathways.

Eiryo Kawakami, Vivek K Singh, Kazuko Matsubara, Takashi Ishii, Yukiko Matsuoka, Takeshi Hase, Priya Kulkarni, Kenaz Siddiqui, Janhavi Kodilkar, Nitisha Danve and 6 more

Abstract read
In one paragraph

Article in NPJ systems biology and applications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. RA-map: building a state-of-the-art interactive knowledge base for rheumatoid arthritis.Database : the journal of biological databases and curation · 2020
    Article
  9. Article
  10. YESdb: integrative analysis of environmental stress in yeast.Database : the journal of biological databases and curation · 2019
    Article
  11. Article
  12. A Link Between Alzheimer's and Type II Diabetes Mellitus? CaBioEssays : news and reviews in molecular, cellular and developmental biology · 2018
    Review
  13. Review
  14. Article
  15. Structure-based control of complex networks with nonlinear dynamics.Proceedings of the National Academy of Sciences of the United States of America · 2017
    Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Eiryo KawakamiLaboratory for Disease Systems Modeling, RIKEN-IMS, Kanagawa, Japan.
Vivek K SinghLABS, Persistent Systems Limited, Pune, India.
Kazuko MatsubaraThe Systems Biology Institute, Tokyo, Japan.
Takashi IshiiLaboratory for Disease Systems Modeling, RIKEN-IMS, Kanagawa, Japan.
Yukiko MatsuokaThe Systems Biology Institute, Tokyo, Japan.ORCID 0000-0002-5171-9096
Takeshi HaseThe Systems Biology Institute, Tokyo, Japan.
Priya KulkarniLABS, Persistent Systems Limited, Pune, India.
Kenaz SiddiquiLABS, Persistent Systems Limited, Pune, India.
Janhavi KodilkarLABS, Persistent Systems Limited, Pune, India.
Nitisha DanveLABS, Persistent Systems Limited, Pune, India.
Indhupriya SubramanianLABS, Persistent Systems Limited, Pune, India.
Manami KatohThe Systems Biology Institute, Tokyo, Japan.
Yuki Shimizu-YoshidaLaboratory for Disease Systems Modeling, RIKEN-IMS, Kanagawa, Japan.
Samik GhoshThe Systems Biology Institute, Tokyo, Japan.
Abhay JereLABS, Persistent Systems Limited, Pune, India.
Hiroaki KitanoLaboratory for Disease Systems Modeling, RIKEN-IMS, Kanagawa, Japan.ORCID 0000-0002-3589-1953

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cellular stress responses require exquisite coordination between intracellular signaling molecules to integrate multiple stimuli and actuate specific cellular behaviors. Deciphering the web of complex interactions underlying stress responses is a key challenge in understanding robust biological systems and has the potential to lead to the discovery of targeted therapeutics for diseases triggered by dysregulation of stress response pathways. We constructed large-scale molecular interaction maps of six major stress response pathways in

Identifiers

PMID28725465
PMCPMC5516916

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.