Evidence map›Paper›PMID 28725420›Full record

ArticleRSC advances2014

A Click Chemistry Approach to Identify Protein Targets of Cancer Chemopreventive Phenethyl Isothiocyanate.

Ying Fu, Lixin Mi, Miloslav Sanda, Shana Silverstein, Monika Aggarwal, Deyun Wang, Pankaj Gupta, Radoslav Goldman, Daniel H Appella, Fung-Lung Chung

Abstract read
In one paragraph

Article in RSC advances, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Synthesis of Isothiocyanates Using DMT/NMM/TsOMolecules (Basel, Switzerland) · 2021
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Ying FuLombardi Cancer Research Centre, Georgetown University, Washington DC, 20007. ; Tel: 202-687-6305.
Lixin MiLombardi Cancer Research Centre, Georgetown University, Washington DC, 20007. ; Tel: 202-687-6305.
Miloslav SandaLombardi Cancer Research Centre, Georgetown University, Washington DC, 20007. ; Tel: 202-687-6305.
Shana SilversteinLombardi Cancer Research Centre, Georgetown University, Washington DC, 20007. ; Tel: 202-687-6305.
Monika AggarwalLombardi Cancer Research Centre, Georgetown University, Washington DC, 20007. ; Tel: 202-687-6305.
Deyun WangNIDDK, National Institutes of Health, Bethesda, MD 20814. ; Tel: 301-451-1052.
Pankaj GuptaNIDDK, National Institutes of Health, Bethesda, MD 20814. ; Tel: 301-451-1052.
Radoslav GoldmanLombardi Cancer Research Centre, Georgetown University, Washington DC, 20007. ; Tel: 202-687-6305.
Daniel H AppellaNIDDK, National Institutes of Health, Bethesda, MD 20814. ; Tel: 301-451-1052.
Fung-Lung ChungLombardi Cancer Research Centre, Georgetown University, Washington DC, 20007. ; Tel: 202-687-6305.
Georgetown University · USNational Institutes of Health · USUniversity of Washington · US

Funding

Tissue Culture Shared ResourceP30CA051008 · NCI · GEORGETOWN UNIVERSITY · PI STEPHEN W BYERS · 1990 to 2026
$71.5M
Glycans in Hepatocellular CarcinomaR01CA135069 · NCI · GEORGETOWN UNIVERSITY · PI GOLDMAN, RADOSLAV · 2009 to 2019
$4.1M
Mechanisms of Chemoprevention by IsothiocyanatesR01CA100853 · NCI · GEORGETOWN UNIVERSITY · PI CHUNG, FUNG-LUNG · 2004 to 2014
$3.3M
NCI NIH HHS P30 CA051008NCI NIH HHS R01 CA100853NCI NIH HHS R01 CA135069
6 · The paper itself

Abstract

Here we report the identification of protein targets of chemopreventive phenethyl isothiocyanate (PEITC) via "click" chemistry in the A549 human lung cancer cell line, using a novel alkyne-tagged PEITC which was also found to show potent

Identifiers

PMID28725420
PMCPMC5512166
OpenAlexW2111712235

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.