ArticleFrontiers in cellular neuroscience2017
Endothelial Nitric Oxide Synthase Is Present in Dendritic Spines of Neurons in Primary Cultures.
Article in Frontiers in cellular neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- Low-Intensity Focused Ultrasound Alters Alzheimer's Disease Pathology, In Vivo, as a Function of Ultrasound Dose and Age.Brain sciences · 2026Article
- A novel brain-to-gut communication pathway mediated by astrocyte-derived small extracellular vesicles modulates stress-induced intestinal inflammation.Molecular psychiatry · 2025Article
- Volatile anesthetics inhibit presynaptic cGMP signaling to depress presynaptic excitability in rat hippocampal neurons.Neuropharmacology · 2023Article
- The eNOS isoform exhibits increased expression and activation in the main olfactory bulb of nNOS knock-out mice.Frontiers in cellular neuroscience · 2023Article
- Structural brain abnormalities in endothelial nitric oxide synthase-deficient mice revealed by high-resolution magnetic resonance imaging.Brain and behavior · 2022Article
- Endothelial Nitric Oxide Synthase in the Perivascular Adipose Tissue.Biomedicines · 2022Review
- The Interplay between cGMP and Calcium Signaling in Alzheimer's Disease.International journal of molecular sciences · 2022Review
- Protective Mechanisms of Nootropic Herb Shankhpushpi (Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Impaired spatial memory in adult vitamin D deficient BALB/c mice is associated with reductions in spine density, nitric oxide, and neural nitric oxide synthase in the hippocampus.AIMS neuroscience · 2022Article
- Nitrergic modulation of ion channel function in regulating neuronal excitability.Channels (Austin, Tex.) · 2021Article
- The Relationship of Glutathione-Molecules (Basel, Switzerland) · 2021Review
- Loss of cholinergic innervation differentially affects eNOS-mediated blood flow, drainage of Aβ and cerebral amyloid angiopathy in the cortex and hippocampus of adult mice.Acta neuropathologica communications · 2021Article
- eNOS-dependent S-nitrosylation of the NF-κB subunit p65 has neuroprotective effects.Cell death & disease · 2021Article
- Nitric Oxide Synthase Inhibitors into the Clinic at Last.Handbook of experimental pharmacology · 2021Article
- A Role for mir-26a in Stress: A Potential sEV Biomarker and Modulator of Excitatory Neurotransmission.Cells · 2020Article
- Nitrosative Stress in the Frontal Cortex From Dogs With Canine Cognitive Dysfunction.Frontiers in veterinary science · 2020Article
- Re-thinking the Etiological Framework of Neurodegeneration.Frontiers in neuroscience · 2019Review
- The temporal expression profile of a Nos3-related natural antisense RNA in the brain suggests a possible role in neurogenesis.Nitric oxide : biology and chemistry · 2017Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nitric oxide exerts important regulatory functions in various brain processes. Its synthesis in neurons has been most commonly ascribed to the neuronal nitric oxide synthase (nNOS) isoform. However, the endothelial isoform (eNOS), which is significantly associated with caveolae in different cell types, has been implicated in synaptic plasticity and is enriched in the dendrites of CA1 hippocampal neurons. Using high resolution microscopy and co-distribution analysis of eNOS with synaptic and raft proteins, we now show for the first time in primary cortical and hippocampal neuronal cultures, virtually devoid of endothelial cells, that eNOS is present in neurons and is localized in dendritic spines. Moreover, eNOS is present in a postsynaptic density-enriched biochemical fraction isolated from these neuronal cultures. In addition, qPCR analysis reveals that both the nNOS as well as the eNOS transcripts are present in neuronal cultures. Moreover, eNOS inhibition in cortical cells has a negative impact on cell survival after excitotoxic stimulation with
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