Trial reportCanadian journal of veterinary research = Revue canadienne de recherche veterinaire2017
The impact of carboplatin and toceranib phosphate on serum vascular endothelial growth factor (VEGF) and metalloproteinase-9 (MMP-9) levels and survival in canine osteosarcoma.
Abstract readClinical Trial
In one paragraph
Trial report in Canadian journal of veterinary research = Revue canadienne de recherche veterinaire, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 23% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 17 citations in OpenAlex.
- Recent Issues in the Development and Application of Targeted Therapies with Respect to Individual Animal Variability.Animals : an open access journal from MDPI · 2025Review
- Osteosarcoma of the appendicular skeleton in dogs: consensus and guidelines.Frontiers in veterinary science · 2025Review
- Global scientific trends on matrix metalloproteinase and osteosarcoma: A bibliometric and visualized analysis.Frontiers in oncology · 2023Article
- Efficacy of Recombinant Human Endostatin plus Neoadjuvant Chemotherapy for Osteosarcoma and Its Influence on Serum VEGF and MMP-9 Levels.Journal of oncology · 2023Article
- Sorafenib and Doxorubicin Show Synergistic Effects in Human and Canine Osteosarcoma Cell Lines.International journal of molecular sciences · 2022Article
- An Update on Molecular Pathways Regulating Vasculogenic Mimicry in Human Osteosarcoma and Their Role in Canine Oncology.Frontiers in veterinary science · 2021Review
- Molecular targets for anticancer therapies in companion animals and humans: what can we learn from each other?Theranostics · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Tracy L GiegerDepartment of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, 1052 William Moore Drive, Raleigh, North Carolina 27607, USA (Gieger, Nettifee-Osborne, Hallman, Johannes, Clarke, Nolan, Williams); Iowa State University College of Veterinary Medicine, 1600 S 16th Street, 1569 LVMC, Ames, Iowa 50011, USA (Johannes); University of Georgia College of Veterinary Medicine, 2200 College Station Road, Athens, Georgia 30602, USA (Clarke); Veterinary Specialty Hospital of the Carolinas, 6405 Tryon Road, Cary, North Carolina 27518, USA (Williams); Comparative Medicine Institute, North Carolina State University, 1052 William Moore Drive, Raleigh, North Carolina 27607, USA (Gieger, Nettifee-Osborne, Nolan).
Julie Nettifee-OsborneDepartment of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, 1052 William Moore Drive, Raleigh, North Carolina 27607, USA (Gieger, Nettifee-Osborne, Hallman, Johannes, Clarke, Nolan, Williams); Iowa State University College of Veterinary Medicine, 1600 S 16th Street, 1569 LVMC, Ames, Iowa 50011, USA (Johannes); University of Georgia College of Veterinary Medicine, 2200 College Station Road, Athens, Georgia 30602, USA (Clarke); Veterinary Specialty Hospital of the Carolinas, 6405 Tryon Road, Cary, North Carolina 27518, USA (Williams); Comparative Medicine Institute, North Carolina State University, 1052 William Moore Drive, Raleigh, North Carolina 27607, USA (Gieger, Nettifee-Osborne, Nolan).
Briana HallmanDepartment of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, 1052 William Moore Drive, Raleigh, North Carolina 27607, USA (Gieger, Nettifee-Osborne, Hallman, Johannes, Clarke, Nolan, Williams); Iowa State University College of Veterinary Medicine, 1600 S 16th Street, 1569 LVMC, Ames, Iowa 50011, USA (Johannes); University of Georgia College of Veterinary Medicine, 2200 College Station Road, Athens, Georgia 30602, USA (Clarke); Veterinary Specialty Hospital of the Carolinas, 6405 Tryon Road, Cary, North Carolina 27518, USA (Williams); Comparative Medicine Institute, North Carolina State University, 1052 William Moore Drive, Raleigh, North Carolina 27607, USA (Gieger, Nettifee-Osborne, Nolan).
Chad JohannesDepartment of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, 1052 William Moore Drive, Raleigh, North Carolina 27607, USA (Gieger, Nettifee-Osborne, Hallman, Johannes, Clarke, Nolan, Williams); Iowa State University College of Veterinary Medicine, 1600 S 16th Street, 1569 LVMC, Ames, Iowa 50011, USA (Johannes); University of Georgia College of Veterinary Medicine, 2200 College Station Road, Athens, Georgia 30602, USA (Clarke); Veterinary Specialty Hospital of the Carolinas, 6405 Tryon Road, Cary, North Carolina 27518, USA (Williams); Comparative Medicine Institute, North Carolina State University, 1052 William Moore Drive, Raleigh, North Carolina 27607, USA (Gieger, Nettifee-Osborne, Nolan).
Dawn ClarkeDepartment of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, 1052 William Moore Drive, Raleigh, North Carolina 27607, USA (Gieger, Nettifee-Osborne, Hallman, Johannes, Clarke, Nolan, Williams); Iowa State University College of Veterinary Medicine, 1600 S 16th Street, 1569 LVMC, Ames, Iowa 50011, USA (Johannes); University of Georgia College of Veterinary Medicine, 2200 College Station Road, Athens, Georgia 30602, USA (Clarke); Veterinary Specialty Hospital of the Carolinas, 6405 Tryon Road, Cary, North Carolina 27518, USA (Williams); Comparative Medicine Institute, North Carolina State University, 1052 William Moore Drive, Raleigh, North Carolina 27607, USA (Gieger, Nettifee-Osborne, Nolan).
Michael W NolanDepartment of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, 1052 William Moore Drive, Raleigh, North Carolina 27607, USA (Gieger, Nettifee-Osborne, Hallman, Johannes, Clarke, Nolan, Williams); Iowa State University College of Veterinary Medicine, 1600 S 16th Street, 1569 LVMC, Ames, Iowa 50011, USA (Johannes); University of Georgia College of Veterinary Medicine, 2200 College Station Road, Athens, Georgia 30602, USA (Clarke); Veterinary Specialty Hospital of the Carolinas, 6405 Tryon Road, Cary, North Carolina 27518, USA (Williams); Comparative Medicine Institute, North Carolina State University, 1052 William Moore Drive, Raleigh, North Carolina 27607, USA (Gieger, Nettifee-Osborne, Nolan).
Laurel E WilliamsDepartment of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, 1052 William Moore Drive, Raleigh, North Carolina 27607, USA (Gieger, Nettifee-Osborne, Hallman, Johannes, Clarke, Nolan, Williams); Iowa State University College of Veterinary Medicine, 1600 S 16th Street, 1569 LVMC, Ames, Iowa 50011, USA (Johannes); University of Georgia College of Veterinary Medicine, 2200 College Station Road, Athens, Georgia 30602, USA (Clarke); Veterinary Specialty Hospital of the Carolinas, 6405 Tryon Road, Cary, North Carolina 27518, USA (Williams); Comparative Medicine Institute, North Carolina State University, 1052 William Moore Drive, Raleigh, North Carolina 27607, USA (Gieger, Nettifee-Osborne, Nolan).
North Carolina State University · US
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this pilot study, 10 dogs with osteosarcoma (OSA) were treated with amputation and subsequent carboplatin chemotherapy (300 mg/m
Indexed as
Amputation, SurgicalAnimalsAntineoplastic AgentsCarboplatinChemotherapy, AdjuvantDog DiseasesDogsDrug Therapy, CombinationFemaleGene Expression Regulation, NeoplasticIndolesMaleMatrix Metalloproteinase 9OsteosarcomaPilot ProjectsPyrrolesAntineoplastic AgentsCarboplatinIndolesMatrix Metalloproteinase 9Pyrrolestoceranib phosphateVascular Endothelial Growth Factor A
Identifiers
PMID
28725110PMC
PMC5508385OpenAlex
W2944394474What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.