ArticleScientific reports2017
Identification of a Flavonoid Glucosyltransferase Involved in 7-OH Site Glycosylation in Tea plants (Camellia sinensis).
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 67 citations in OpenAlex.
- A Comprehensive Review of Natural and Synthetic Flavonoids as Antibiofilm Agents Against Bacterial Biofilms.Current microbiology · 2026Review
- Tomato pollen tube growth requires flavonol glycosylation.Plant physiology · 2025Article
- Influencing Factors and Regulatory Mechanisms of Fresh Tea Leaf Quality: A Review.Foods (Basel, Switzerland) · 2025Review
- Functional analysis of a UDP-glucosyltransferase gene contributing to biosynthesis of the flavonol triglycoside in tea plants.Horticulture research · 2025Article
- Identification and functional characterization of a new flavonoid glycosyltransferase fromChinese herbal medicines · 2025Article
- Biosynthesis and Physiological Significance of Organ-Specific Flavonol Glycosides in Solanaceae.bioRxiv : the preprint server for biology · 2025Article
- Review
- Genome-wide analysis of UDP-glycosyltransferases family and identification of UGT genes involved in drought stress ofFrontiers in plant science · 2024Article
- Al-induced CsUGT84J2 enhances flavonol and auxin accumulation to promote root growth in tea plants.Horticulture research · 2023Article
- Study on the Comprehensive Phytochemicals and the Anti-Ulcerative Colitis Effect ofMolecules (Basel, Switzerland) · 2023Article
- Integration of genome-wide association studies, metabolomics, and transcriptomics reveals phenolic acid- and flavonoid-associated genes and their regulatory elements under drought stress in rapeseed flowers.Frontiers in plant science · 2023Article
- Genome-wide identification of UDP-glycosyltransferases in the tea plant (Frontiers in plant science · 2023Review
- Identification and Characterization of Two Bibenzyl Glycosyltransferases from the LiverwortAntioxidants (Basel, Switzerland) · 2022Article
- Biochemistry and Molecular Basis of Intracellular Flavonoid Transport in Plants.Plants (Basel, Switzerland) · 2022Review
- Characterization of UDP-glycosyltransferase family members reveals how major flavonoid glycoside accumulates in the roots of Scutellaria baicalensis.BMC genomics · 2022Article
- Genome-wide identification, characterization, and expression analysis of UDP-glycosyltransferase genes associated with secondary metabolism in alfalfa (Frontiers in plant science · 2022Article
- Transcriptomic, Proteomic and Metabolomic Analysis of Flavonoid Biosynthesis During Fruit Maturation inFrontiers in plant science · 2021Article
- Functional characterization and reclassification of an enzyme previously proposed to be a limonoid UDP-glucosyltransferase.Journal of the science of food and agriculture · 2020Article
- Engineering of Cyclodextrin Glycosyltransferase Reveals pH-Regulated Mechanism of Enhanced Long-Chain Glycosylated Sophoricoside Specificity.Applied and environmental microbiology · 2020Article
- Family-1 UDP glycosyltransferases in pear (Pyrus bretschneideri): Molecular identification, phylogenomic characterization and expression profiling during stone cell formation.Molecular biology reports · 2019Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Flavonol glycosides, which are often converted from aglycones in a process catalyzed by UDP-glycosyltransferases (UGTs), play an important role for the health of plants and animals. In the present study, a gene encoding a flavonoid 7-O-glycosyltransferase (CsUGT75L12) was identified in tea plants. Recombinant CsUGT75L12 protein displayed glycosyltransferase activity on the 7-OH position of multiple phenolic compounds. In relative comparison to wild-type seeds, the levels of flavonol-glucosides increased in Arabidopsis seeds overexpressing CsUGT75L12. In order to determine the key amino acid residues responsible for the catalytic activity of the protein, a series of site-directed mutagenesis and enzymatic assays were performed based on the 3D structural modeling and docking analyses. These results suggested that residue Q54 is a double binding site that functions as both a sugar receptor and donor. Residues H56 and T151, corresponding to the basic active residues H20 and D119 of VvGT1, were not irreplaceable for CsUGT75L12. In addition, residues Y182, S223, P238, T239, and F240 were demonstrated to be responsible for a 'reversed' sugar receptor binding model. The results of single and triple substitutions confirmed that the function of residues P238, T239, and F240 may substitute or compensate with each other for the flavonoid 7-O-glycosyltransferase activity.
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