ArticleScientific reports2017
Serum albumin and osmolality inhibit Bdellovibrio bacteriovorus predation in human serum.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 34 citations in OpenAlex.
- From microbes to animals: a review on prey choice and prey-predator dynamics across organismal scales.FEMS microbiology reviews · 2026Review
- Test parameter selection affects the perceived antibacterial efficacy of a contact-killing coating developed to prevent prosthetic joint infection.Frontiers in bioengineering and biotechnology · 2026Article
- Predatory bacteria can intensify lung-injury in a multidrug-resistantFrontiers in microbiology · 2025Article
- Predation on bacterial pathogens by predatory bacteria of sewage origin: three days prey-predator interactions.BMC microbiology · 2024Article
- How do Gram-negative bacteria escape predation by Bdellovibrio bacteriovorus?npj antimicrobials and resistance · 2024Review
- Two-state swimming: Strategy and survival of a model bacterial predator in response to environmental cues.Biophysical journal · 2023Article
- Use of Resazurin To Rapidly EnumerateMicrobiology spectrum · 2022Article
- Biological Control ofMicroorganisms · 2022Review
- Predation Strategies of the Bacterium Bdellovibrio bacteriovorus Result in Overexploitation and Bottlenecks.Applied and environmental microbiology · 2022Article
- The role of mathematical modelling in understanding prokaryotic predation.Frontiers in microbiology · 2022Review
- Diffusible Signaling Factor, a Quorum-Sensing Molecule, Interferes with and Is Toxic Towards Bdellovibrio bacteriovorus 109J.Microbial ecology · 2021Article
- Insight into the Possible Use of the PredatorNutrients · 2020Review
- Compounds affecting predation by and viability of predatory bacteria.Applied microbiology and biotechnology · 2020Review
- The antibiotic crisis: How bacterial predators can help.Computational and structural biotechnology journal · 2020Review
- Engulfment, persistence and fate of Bdellovibrio bacteriovorus predators inside human phagocytic cells informs their future therapeutic potential.Scientific reports · 2019Article
- Combined Application of Bacterial Predation and Violacein to Kill Polymicrobial Pathogenic Communities.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We evaluated the bactericidal activity of Bdellovibrio bacteriovorus, strain HD100, within blood sera against bacterial strains commonly associated with bacteremic infections, including E. coli, Klebsiella pneumoniae and Salmonella enterica. Tests show that B. bacteriovorus HD100 is not susceptible to serum complement or its bactericidal activity. After a two hour exposure to human sera, the prey populations decreased 15- to 7,300-fold due to the serum complement activity while, in contrast, the B. bacteriovorus HD100 population showed a loss of only 33%. Dot blot analyses showed that this is not due to the absence of antibodies against this predator. Predation in human serum was inhibited, though, by both the osmolality and serum albumin. The activity of B. bacteriovorus HD100 showed a sharp transition between 200 and 250 mOsm/kg, and was progressively reduced as the osmolality increased. Serum albumin also acted to inhibit predation by binding to and coating the predatory cells. This was confirmed via dot blot analyses and confocal microscopy. The results from both the osmolality and serum albumin tests were incorporated into a numerical model describing bacterial predation of pathogens. In conclusion, both of these factors inhibit predation and, as such, they limit its effectiveness against pathogenic prey located within sera.
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Registered trials
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