Evidence map›Paper›PMID 28724990›Full record

SynthesisNature communications2017

Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.

M Carola Zillikens, Serkalem Demissie, Yi-Hsiang Hsu, Laura M Yerges-Armstrong, Wen-Chi Chou, Lisette Stolk, Gregory Livshits, Linda Broer, Toby Johnson, Daniel L Koller and 183 more

Erratum issuedAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 117 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
117citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

117 citing papers in PubMed, 7 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Four pleiotropic loci associated with fat mass and lean mass.International journal of obesity (2005) · 2020
    Pooled it
  6. Pooled it
  7. Pooled it
  8. Trial
  9. Trial
  10. Loss ofiScience · 2026
    Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. An Overview of ADAMTS Proteases.Methods in molecular biology (Clifton, N.J.) · 2026
    Review
  20. The Genetic Blueprint of Obesity: From Pathogenesis to Novel Therapies.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025
    Review

57 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

193 authors.

M Carola ZillikensDepartment of Internal Medicine, Erasmus MC, Rotterdam, 3000, The Netherlands.
Serkalem DemissieDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, 02118, USA.
Yi-Hsiang HsuHebrew SeniorLife, Institute for Aging Research, Roslindale, MA, 02131, USA.
Laura M Yerges-ArmstrongProgram in Personalized and Genomic Medicine, and Department of Medicine, Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
Wen-Chi ChouHebrew SeniorLife, Institute for Aging Research, Roslindale, MA, 02131, USA.
Lisette StolkDepartment of Internal Medicine, Erasmus MC, Rotterdam, 3000, The Netherlands.
Gregory LivshitsSackler Faculty of Medicine, Department of Anatomy and Anthropology, Tel Aviv University, Tel Aviv, 6997801, Israel.
Linda BroerDepartment of Epidemiology, Erasmus MC, Rotterdam, 3000, The Netherlands.
Toby JohnsonDepartment of Medical Genetics, University of Lausanne, Lausanne, 1011, Switzerland.
Daniel L KollerDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Zoltán KutalikDepartment of Medical Genetics, University of Lausanne, Lausanne, 1011, Switzerland.
Jian'an LuanMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, CB2 OQQ, UK.
Ida MalkinSackler Faculty of Medicine, Department of Anatomy and Anthropology, Tel Aviv University, Tel Aviv, 6997801, Israel.
Janina S RiedInstitute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, 85764, Germany.
Albert V SmithIcelandic Heart Association, Kopavogur, 201, Iceland.
Gudmar ThorleifssondeCODE Genetics, Reykjavik, 101, Iceland.
Liesbeth VandenputDepartment of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, SE-405 30, Sweden.
Jing Hua ZhaoMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, CB2 OQQ, UK.
Weihua ZhangDepartment Epidemiology and Biostatistics, School of Public Health, Imperial College, London, SW7 2AZ, UK.
Ali AghdassiDepartment of Medicine A, University of Greifswald, Greifswald, 17489, Germany.
Kristina ÅkessonDepartment of Clinical Sciences, Lund University, Malmö, 22362, Sweden.
Najaf AminDepartment of Epidemiology, Erasmus MC, Rotterdam, 3000, The Netherlands.
Leslie J BaierPhoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Phoenix, AZ, 85014, USA.
Inês BarrosoWellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, CB10 1SA, UK.
David A BennettRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, 60612, USA.
Lars BertramLübeck Interdisciplinary Platform for Genome Analytics, Institutes of Neurogenetics and Experimental & Integrative Genomics, University of Lübeck, Lübeck, 23562, Germany.
Rainer BiffarCentre of Oral Health, Department of Prosthetic Dentistry, Gerodontology and Biomaterials, University of Greifswald, Greifswald, 17489, Germany.
Murielle BochudCentre Hospitalier Universitaire (CHUV), University Institute for Social and Preventive Medicine, Lausanne, 1010, Switzerland.
Michael BoehnkeDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, 48109, USA.
Ingrid B BoreckiDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St Louis, MO, 63110, USA.
Aron S BuchmanRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, 60612, USA.
Liisa BybergDepartment of Surgical Sciences, Uppsala University, Uppsala, 75185, Sweden.
Harry CampbellUsher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland, EH8 9AG, UK.
Natalia Campos ObandaDepartment of Internal Medicine, Erasmus MC, Rotterdam, 3000, The Netherlands.
Jane A CauleyDepartment of Epidemiology Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, 15261, USA.
Peggy M CawthonCalifornia Pacific Medical Center Research Institute, San Francisco, CA, 94107, USA.
Henna CederbergDepartment of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, 70210, Finland.
Zhao ChenMel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ, 85714, USA.
Nam H ChoDepartment of Preventive Medicine, Ajou University School of Medicine, Youngtong-Gu, Suwon, 16499, Korea.
Hyung Jin ChoiDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, 03080, Korea.
Melina ClaussnitzerHebrew SeniorLife, Institute for Aging Research, Roslindale, MA, 02131, USA.
Francis CollinsMedical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, Bethesda, MD, 20892, USA.
Steven R CummingsCalifornia Pacific Medical Center Research Institute, San Francisco, CA, 94107, USA.
Philip L De JagerHarvard Medical School, Boston, MA, 02115, USA.
Ilja DemuthLipid Clinic at the Interdisciplinary Metabolism Center, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, 13353, Germany.
Rosalie A M Dhonukshe-RuttenDepartment of Human Nutrition, Wageningen University, PO Box 17, Wageningen, 6700 AA, The Netherlands.
Luda DiatchenkoAlan Edwards Centre for Research on Pain, McGill University, Montreal, H3A 0G1, Canada.
Gudny EiriksdottirIcelandic Heart Association, Kopavogur, 201, Iceland.
Anke W EnnemanDepartment of Internal Medicine, Erasmus MC, Rotterdam, 3000, The Netherlands.
Mike ErdosMedical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, Bethesda, MD, 20892, USA.
Johan G ErikssonDepartment of General Practice and Primary Health Care, University of Helsinki, Helsinki, 00014, Finland.
Joel ErikssonDepartment of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, SE-405 30, Sweden.
Karol EstradaDepartment of Internal Medicine, Erasmus MC, Rotterdam, 3000, The Netherlands.
Daniel S EvansCalifornia Pacific Medical Center Research Institute, San Francisco, CA, 94107, USA.
Mary F FeitosaDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St Louis, MO, 63110, USA.
Mao FuProgram in Personalized and Genomic Medicine, and Department of Medicine, Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
Melissa GarciaLaboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute for Aging, Bethesda, MD, 20892, USA.
Christian GiegerInstitute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, 85764, Germany.
Thomas GirkeInstitute for Integrative Genome Biology, University of California, Riverside, CA, 92521, USA.
Nicole L GlazerDepartments of Medicine and Epidemiology, Boston University School of Medicine and Public Health, Boston, MA, 02118, USA.
Harald GrallertInstitute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, 85764, Germany.
Jagvir GrewalCardiology Department, Ealing Hospital NHS Trust, Middlesex, UB1 3HW, UK.
Bok-Ghee HanCenter for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, 28159, Korea.
Robert L HansonPhoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Phoenix, AZ, 85014, USA.
Caroline HaywardMRC Human Genetics Unit, IGMM, University of Edinburgh, Edinburgh, Scotland, EH4 2XU, UK.
Albert HofmanNetherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Leiden, 2593, The Netherlands.
Eric P HoffmanDepartment of Pharmaceutical Sciences, SUNY Binghamton, Binghamton, NY, 13902, USA.
Georg HomuthInterfaculty Institute for Genetics and Functional Genomics, University of Greifswald, Greifswald, 17487, Germany.
Wen-Chi HsuehPhoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Phoenix, AZ, 85014, USA.
Monica J HubalDepartment of Exercise and Nutrition Sciences, George Washington University, Washington, DC, 20052, USA.
Alan HubbardDivision of Biostatistics, School of Public Health, University of California, Berkeley, CA, 94720, USA.
Kim M HuffmanDivision of Rheumatology, Department of Medicine, Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, 27710, USA.
Lise B HustedEndocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, DK 8000, Denmark.
Thomas IlligResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, 85764, Germany.
Erik IngelssonDepartment of Medical Sciences, Uppsala University, Uppsala, 75185, Sweden.
Till IttermannInstitute for Community Medicine, University of Greifswald, Greifswald, 17489, Germany.
John-Olov JanssonDepartment of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, SE 405 30, Sweden.
Joanne M JordanThurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27517, USA.
Antti JulaNational Institute for Health and Welfare, Helsinki, 00271, Finland.
Magnus KarlssonDepartment of Clinical Sciences and Orthopaedics, Lund University, Skåne University Hospital SUS, Malmö, 22362, Sweden.
Kay-Tee KhawDepartment of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK.
Tuomas O KilpeläinenMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, CB2 OQQ, UK.
Norman KloppResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, 85764, Germany.
Jacqueline S L KlothDepartment of Internal Medicine, Erasmus MC, Rotterdam, 3000, The Netherlands.
Heikki A KoistinenDepartment of Medicine, University of Helsinki and Helsinki University Central Hospital, Helsinki, 00029, Finland.
William E KrausDivision of Cardiology, Department of Medicine, Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, 27710, USA.
Stephen KritchevskySticht Center on Aging, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USA.
Teemu KuulasmaaDepartment of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, 70210, Finland.
Johanna KuusistoDepartment of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, 70210, Finland.
Markku LaaksoDepartment of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, 70210, Finland.
Jari LahtiInstitute of Behavioural Sciences, University of Helsinki, Helsinki, FI00014, Finland.
Thomas LangUniversity of California San Francisco, San Francisco, CA, 94143, USA.
Bente L LangdahlEndocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, DK 8000, Denmark.
Lenore J LaunerLaboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute for Aging, Bethesda, MD, 20892, USA.
Jong-Young LeeCenter for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, 28159, Korea.
Markus M LerchDepartment of Medicine A, University of Greifswald, Greifswald, 17489, Germany.
Joshua R LewisSchool of Medicine and Pharmacology, University of Western Australia, Perth, 6009, Australia.
Lars LindDepartment of Medical Sciences, Uppsala University, Uppsala, 75185, Sweden.
Cecilia LindgrenWellcome Trust Centre for Human Genetics, Oxford University, Oxford, OX3 7BN, UK.
Yongmei LiuDepartment of Epidemiology and Prevention, Wake Forest School of Medicine, Winston-Salem, NC, 27517, USA.
Tian LiuMax Planck Institute for Molecular Genetics, Berlin, 14195, Germany.
Youfang LiuThurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27517, USA.
Östen LjunggrenDepartment of Medical Sciences, Uppsala University, Uppsala, 75185, Sweden.
Mattias LorentzonDepartment of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, SE-405 30, Sweden.
Robert N LubenDepartment of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK.
William MaixnerRegional Center for Neurosensory Disorders, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Fiona E McGuiganDepartment of Clinical Sciences, Lund University, Malmö, 22362, Sweden.
Carolina Medina-GomezDepartment of Internal Medicine, Erasmus MC, Rotterdam, 3000, The Netherlands.
Thomas MeitingerInstitute of Human Genetics, MRI, Technische Universität München, Munich, 81675, Germany.
Håkan MelhusDepartment of Medical Sciences, Uppsala University, Uppsala, 75185, Sweden.
Dan MellströmDepartment of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, SE-405 30, Sweden.
Simon MelovBuck Institute for Research on Aging, Novato, CA, 94945, USA.
Karl MichaëlssonDepartment of Surgical Sciences, Uppsala University, Uppsala, 75185, Sweden.
Braxton D MitchellProgram in Personalized and Genomic Medicine, and Department of Medicine, Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
Andrew P MorrisWellcome Trust Centre for Human Genetics, Oxford University, Oxford, OX3 7BN, UK.
Leif MosekildeEndocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, DK 8000, Denmark.
Anne NewmanCenter for Aging and Population Health, University of Pittsburgh, Pittsburgh, PA, 15261, USA.
Carrie M NielsonOregon Health & Science University, Portland, OR, 97239, USA.
Jeffrey R O'ConnellProgram in Personalized and Genomic Medicine, and Department of Medicine, Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
Ben A OostraDepartment of Clinical Genetics, Erasmus MC, Rotterdam, 300 CA, The Netherlands.
Eric S OrwollOregon Health & Science University, Portland, OR, 97239, USA.
Aarno PalotieInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, 00251, Finland.
Stephen C J ParkerHuman Genetics and Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, 48109, USA.
Munro PeacockDepartment of Medicine, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Markus PerolaNational Institute for Health and Welfare, Helsinki, 00271, Finland.
Annette PetersInstitute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, 85764, Germany.
Ozren PolasekFaculty of Medicine, Department of Public Health, University of Split, Split, 21000, Croatia.
Richard L PrinceSchool of Medicine and Pharmacology, University of Western Australia, Perth, 6009, Australia.
Katri RäikkönenInstitute of Behavioural Sciences, University of Helsinki, Helsinki, FI00014, Finland.
Stuart H RalstonMolecular Medicine Centre, MRC Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, Scotland, EH4 2XU, UK.
Samuli RipattiInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, 00251, Finland.
John A RobbinsDepartment of Medicine, University of California at Davis, Sacramento, CA, 95817, USA.
Jerome I RotterInstitute for Translational Genomic and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor UCLA Medical Center, Torrance, CA, 90502, USA.
Igor RudanUsher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland, EH8 9AG, UK.
Veikko SalomaaNational Institute for Health and Welfare, Helsinki, 00271, Finland.
Suzanne SatterfieldDepartment of Preventive Medicine, University of Tennessee Health Science Center, Memphis, TN, 38163, USA.
Eric E SchadtDepartment of Genetics and Genomic Science, Institute of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Sabine SchipfInstitute for Community Medicine, University of Greifswald, Greifswald, 17489, Germany.
Laura ScottDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, 48109, USA.
Joban SehmiCardiology Department, Ealing Hospital NHS Trust, Middlesex, UB1 3HW, UK.
Jian ShenOregon Health & Science University, Portland, OR, 97239, USA.
Chan Soo ShinDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, 03080, Korea.
Gunnar SigurdssonFaculty of Medicine, University of Iceland, Reykjavik, 101, Iceland.
Shad SmithCenter for Translational Pain Medicine, Department of Anesthiology, Duke University Medical Center, Durham, NC, 27110, USA.
Nicole SoranzoWellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, CB10 1SA, UK.
Alena StančákováDepartment of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, 70210, Finland.
Elisabeth Steinhagen-ThiessenLipid Clinic at the Interdisciplinary Metabolism Center, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, 13353, Germany.
Elizabeth A StreetenProgram in Personalized and Genomic Medicine, and Department of Medicine, Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
Unnur StyrkarsdottirdeCODE Genetics, Reykjavik, 101, Iceland.
Karin M A SwartDepartment of Epidemiology and Biostatistics, and the EMGO Institute, VU University Medical Center, Amsterdam, BT1081, The Netherlands.
Sian-Tsung TanCardiology Department, Ealing Hospital NHS Trust, Middlesex, UB1 3HW, UK.
Mark A TarnopolskyDepartment of Medicine, McMaster University Medical Center, Hamilton, ON, Canada, L8N 3Z5.
Patricia ThompsonDepartment of Pathology, Stony Brook School of Medicine, Stony Brook, NY, 11794, USA.
Cynthia A ThomsonMel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ, 85714, USA.
Unnur ThorsteinsdottirFaculty of Medicine, University of Iceland, Reykjavik, 101, Iceland.
Emmi TikkanenNational Institute for Health and Welfare, Helsinki, 00271, Finland.
Gregory J TranahCalifornia Pacific Medical Center Research Institute, San Francisco, CA, 94107, USA.
Jaakko TuomilehtoVasa Central Hospital, Vasa, 65130, Finland.
Natasja M van SchoorDepartment of Epidemiology and Biostatistics, and the EMGO Institute, VU University Medical Center, Amsterdam, BT1081, The Netherlands.
Arjun VermaCardiology Department, Ealing Hospital NHS Trust, Middlesex, UB1 3HW, UK.
Peter VollenweiderDepartment of Medicine and Internal Medicine, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, CH-1011, Switzerland.
Henry VölzkeInstitute for Community Medicine, University of Greifswald, Greifswald, 17489, Germany.
Jean Wactawski-WendeDepartment of Epidemiology and Environmental Health, University at Buffalo, State University of New York, Buffalo, NY, 14214, USA.
Mark WalkerInstitute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.
Michael N WeedonGenetics of Complex Traits, University of Exeter Medical School, Exeter, EX1 2LU, UK.
Ryan WelchDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, 48109, USA.
H-Erich WichmannInstitute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, 85764, Germany.
Elisabeth WidenInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, 00251, Finland.
Frances M K WilliamsDepartment of Twin Research and Genetic Epidemiology, King's College London, St Thomas' Campus, London, WC2R 2LS, UK.
James F WilsonUsher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland, EH8 9AG, UK.
Nicole C WrightDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
Weijia XieGenetics of Complex Traits, University of Exeter Medical School, Exeter, EX1 2LU, UK.
Lei YuRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, 60612, USA.
Yanhua ZhouDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, 02118, USA.
John C ChambersDepartment Epidemiology and Biostatistics, School of Public Health, Imperial College, London, SW7 2AZ, UK.
Angela DöringInstitute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, 85764, Germany.
Cornelia M van DuijnDepartment of Epidemiology, Erasmus MC, Rotterdam, 3000, The Netherlands.
Michael J EconsDepartment of Medicine and Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Vilmundur GudnasonIcelandic Heart Association, Kopavogur, 201, Iceland.
Jaspal S KoonerCardiology Department, Ealing Hospital NHS Trust, Middlesex, UB1 3HW, UK.
Bruce M PsatyDepartments of Medicine, Epidemiology, and Health Services, Cardiovascular Health Research Unit, University of Washington, Seattle, WA, 98101, USA.
Timothy D SpectorDepartment of Twin Research and Genetic Epidemiology, King's College London, St Thomas' Campus, London, WC2R 2LS, UK.
Kari StefanssonFaculty of Medicine, University of Iceland, Reykjavik, 101, Iceland.
Fernando RivadeneiraDepartment of Internal Medicine, Erasmus MC, Rotterdam, 3000, The Netherlands.
André G UitterlindenDepartment of Internal Medicine, Erasmus MC, Rotterdam, 3000, The Netherlands.
Nicholas J WarehamMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, CB2 OQQ, UK.
Vicky OssowskiPhoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Phoenix, AZ, 85014, USA.
Dawn WaterworthMedical Genetics, GlaxoSmithKline, Philadelphia, PA, 19112, USA.
Ruth J F LoosMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, CB2 OQQ, UK.
David KarasikHebrew SeniorLife, Institute for Aging Research, Roslindale, MA, 02131, USA.
Tamara B HarrisLaboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute for Aging, Bethesda, MD, 20892, USA.
Claes OhlssonDepartment of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, SE-405 30, Sweden.
Douglas P KielHebrew SeniorLife, Institute for Aging Research, Roslindale, MA, 02131, USA. kiel@hsl.harvard.edu.

Funding

Oregon Clinical and Translational Research Institute - The National COVID Cohort Collaborative (N3C)UL1TR002369 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI Cynthia D Morris, Christopher G. Slatore · 2017 to 2026
$78.4M
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
EPIDEMIOLOGY OF NEURAL RESERVE AND NEUROBIOLOGY IN AGINGR01AG017917 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2001 to 2023
$43.3M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4M
Genetic analysis of type II diabetes in Finnish populationZIAHG000024 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI ERDOS, MICHAEL · 2009 to 2025
$38.2M
PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Edward L Melanson · 1995 to 2026
$32.6M
Oregon Clinical and Translational Research InstituteUL1TR000128 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI ELLISON, DAVID H · 2012 to 2015
$28.7M
Translational Research CoreP30DK020541 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI STREAMSON C CHUA · 2015 to 2026
$27.7M
ZOSUQUIDAR TRIHYDROCHLORIDE DURING CONVENTIONAL INDUCTION AND POST-REMISSIONM01RR000750 · NCRR · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI STORNIOLO, ANNA · 1985 to 2008
$25.5M
Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3M
Study of Osteoporotic FracturesR01AG005407 · NIA · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI CUMMINGS, STEVEN RON, YAFFE, KRISTINE · 1986 to 2016
$23.2M
RISK FACTORS, PATHOLOGY, AND CLINICAL EXPRESSIONS OF ADR01AG015819 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 1998 to 2024
$21.4M
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6 · The paper itself

Abstract

Lean body mass, consisting mostly of skeletal muscle, is important for healthy aging. We performed a genome-wide association study for whole body (20 cohorts of European ancestry with n = 38,292) and appendicular (arms and legs) lean body mass (n = 28,330) measured using dual energy X-ray absorptiometry or bioelectrical impedance analysis, adjusted for sex, age, height, and fat mass. Twenty-one single-nucleotide polymorphisms were significantly associated with lean body mass either genome wide (p < 5 × 10

Indexed as

Genome-Wide Association Study17-Hydroxysteroid DehydrogenasesADAMTS ProteinsAldehyde OxidoreductasesAlpha-Ketoglutarate-Dependent Dioxygenase FTOBody CompositionExtracellular Matrix ProteinsHumansInsulin Receptor Substrate ProteinsPhenotypePolymorphism, Single NucleotideQuantitative Trait LociRegulatory Elements, TranscriptionalThinnessVersicans17-Hydroxysteroid DehydrogenasesADAMTSL3 protein, humanADAMTS ProteinsAldehyde OxidoreductasesAlpha-Ketoglutarate-Dependent Dioxygenase FTOExtracellular Matrix ProteinsFTO protein, humanHSD17B11 protein, humanInsulin Receptor Substrate ProteinsIRS1 protein, humanVCAN protein, humanVersicans

Identifiers

PMID28724990
PMCPMC5517526

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