ArticleScientific reports2017
pH and Urea Estimation in Urine Samples using Single Fluorophore and Ratiometric Fluorescent Biosensors.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 43 citations in OpenAlex.
- Biosensing of Urea with a Functionalized Gold Electrode for Health and Food Monitoring.Journal of agricultural and food chemistry · 2025Article
- Transformative biomedical devices to overcome biomatrix effects.Biosensors & bioelectronics · 2025Review
- Green and sustainable synthesis of CaO nanoparticles: Its solicitation as a sensor material and electrochemical detection of urea.Scientific reports · 2023Article
- Design and Detection of Cyanide Raman Tag pH-Responsive SERS Probes.Biosensors · 2022Article
- Developing a fluorometric urease activity microplate assay suitable for automated microbioreactor experiments.Frontiers in bioengineering and biotechnology · 2022Article
- Simple monitoring of pH and urea in whole blood using wearable smart woman pad.BioImpacts : BI · 2022Article
- Pentacyanoammineferrate-Based Non-Enzymatic Electrochemical Biosensing Platform for Selective Uric Acid Measurement.Sensors (Basel, Switzerland) · 2021Article
- Ultrasonic atomizer based development of pH sensor for real time analysis.Scientific reports · 2020Article
- Flexible potentiometric pH sensors for wearable systems.RSC advances · 2020Review
- Fluorescent Biocompatible Platinum-Porphyrin-Doped Polymeric Hybrid Particles for Oxygen and Glucose Biosensing.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Kidney diseases remain often undiagnosed due to inefficient screening methods available at patient's disposal. Early diagnosis and effective management of kidney problems can best be addressed by the development of biosensors for commonly occurring clinical biomarkers. Here we report the development of single fluorophore and dual fluorophore ratiometric biosensors based on alginate microspheres for pH and urea analysis in urine samples. A facile method of air driven atomization was used for developing these polymeric fluorophore and enzyme based biosensors. Ratiometric biosensors were developed using layer-by-layer coating of polyelectrolyte conjugated to reference fluorophores. Biosensing studies using these biosensors showed that samples in pathophysiological range can be measured having pH range of 4-8 and urea levels between 0-50 mM. Testing of urine samples using these biosensors showed that both pH and urea detection can be accurately performed without interference. Thus, we believe that FITC-Dextran and FITC-Dextran/RuBpy based pH and urea biosensors show a great potential to be translated as a point of care device for pH and urea biosensing in early detection and continuous monitoring of kidney diseases.
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