ArticleScientific reports2017
Nanocapsules Containing Neem (Azadirachta Indica) Oil: Development, Characterization, And Toxicity Evaluation.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Nanopesticides: A Systematic Review of Their Prospects With Special Reference to Tea Pest Management.Frontiers in nutrition · 2021Pooled it
- Article
- Difenoconazole-Loaded Nanostructured Lipid Carriers: Preparation, Characterization, and Evaluation.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Synthesis, Characterization, Phytochemistry, and Therapeutic Potential of Azadirachta indica Conjugated Silver Nanoparticles: A Comprehensive Study on Antidiabetic and Antioxidant Properties.Biological trace element research · 2025Article
- Biosynthesis of nickel nanoparticles using Enterobacter cloacae: characterization and multifaceted applications.Biologia futura · 2025Article
- Titanium biogenic nanoparticles to help the growth of Trichoderma harzianum to be used in biological control.Journal of nanobiotechnology · 2023Article
- Deciphering the key pathway for triterpenoid biosynthesis inFrontiers in plant science · 2023Review
- Unravelling the Therapeutic Potential of Nano-Delivered Functional Foods in Chronic Respiratory Diseases.Nutrients · 2022Review
- Formulation of Neem oil-loaded solid lipid nanoparticles and evaluation of its anti-Toxoplasma activity.BMC complementary medicine and therapies · 2022Article
- Nano-enabled pesticides for sustainable agriculture and global food security.Nature nanotechnology · 2022Article
- Stability Phenomena Associated with the Development of Polymer-Based Nanopesticides.Oxidative medicine and cellular longevity · 2022Review
- The Antimicrobial Potential of the Neem TreeFrontiers in pharmacology · 2022Review
- Smart nanomaterial and nanocomposite with advanced agrochemical activities.Nanoscale research letters · 2021Review
- Essential Oil-Loaded NLC for Potential Intranasal Administration.Pharmaceutics · 2021Article
- Article
- Article
- Sorption, persistence, and leaching of the allelochemical umbelliferone in soils treated with nanoengineered sorbents.Scientific reports · 2019Article
- Pesticide Encapsulation at the Nanoscale Drives Changes to the Hydrophobic Partitioning and Toxicity of an Active Ingredient.Nanomaterials (Basel, Switzerland) · 2019Article
- Synthesis of biogenic silver nanoparticles using Althaea officinalis as reducing agent: evaluation of toxicity and ecotoxicity.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, we prepared, characterized, and performed toxicity analyses of poly(ε-caprolactone) nanocapsules loaded with neem oil. Three formulations were prepared by the emulsion/solvent evaporation method. The nanocapsules showed a mean size distribution around 400 nm, with polydispersity below 0.2 and were stable for 120 days. Cytotoxicity and genotoxicity results showed an increase in toxicity of the oleic acid + neem formulations according to the amount of oleic acid used. The minimum inhibitory concentrations demonstrated that all the formulations containing neem oil were active. The nanocapsules containing neem oil did not affect the soil microbiota during 300 days of exposure compared to the control. Phytotoxicity studies indicated that NC_20 (200 mg of neem oil) did not affect the net photosynthesis and stomatal conductance of maize plants, whereas use of NC_10 (100:100 of neem:oleic acid) and NC_15 (150:50 of neem:oleic acid) led to negative effects on these physiological parameters. Hence, the use of oleic acid as a complement in the nanocapsules was not a good strategy, since the nanocapsules that only contained neem oil showed lower toxicity. These results demonstrate that evaluation of the toxicity of nanopesticides is essential for the development of environmentally friendly formulations intended for applications in agriculture.
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Registered trials
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