ArticleScientific reports2017
On wakefulness fluctuations as a source of BOLD functional connectivity dynamics.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04799795 (Objective EEG Bed Side Assessment of Impaired Conscious Awareness in Epilepsy), which is not on this map. Cited by 40 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Objective EEG Bed Side Assessment of Impaired Conscious Awareness in Epilepsy
Who cites it
40 citing papers in PubMed.
- Article
- The Awakening Brain is Characterized by a Widespread and Spatiotemporally Heterogeneous Increase in High Frequencies.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Brain connectivity correlates of breathing and cardiac patterns in epilepsy: A study including SUDEP cases.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Topological state-space estimation of functional human brain networks.PLoS computational biology · 2024Article
- A predictor-informed multi-subject bayesian approach for dynamic functional connectivity.PloS one · 2024Article
- Graph-matching distance between individuals' functional connectomes varies with relatedness, age, and cognitive score.Human brain mapping · 2023Article
- Article
- Reorganization of the functional connectome from rest to a visual perception task in schizophrenia and bipolar disorder.Psychiatry research. Neuroimaging · 2022Article
- Article
- Arousal impacts distributed hubs modulating the integration of brain functional connectivity.NeuroImage · 2022Article
- Functional Connectivity of the Brain Across Rodents and Humans.Frontiers in neuroscience · 2022Review
- State-related neural influences on fMRI connectivity estimation.NeuroImage · 2021Review
- Decoding brain states on the intrinsic manifold of human brain dynamics across wakefulness and sleep.Communications biology · 2021Article
- Multimodal EEG-fMRI: advancing insight into large-scale human brain dynamics.Current opinion in biomedical engineering · 2021Article
- NREM sleep stages specifically alter dynamical integration of large-scale brain networks.iScience · 2021Article
- Dynamic brain fluctuations outperform connectivity measures and mirror pathophysiological profiles across dementia subtypes: A multicenter study.NeuroImage · 2021Article
- Connectivity dynamics from wakefulness to sleep.NeuroImage · 2020Article
- Dynamical Mechanisms of Interictal Resting-State Functional Connectivity in Epilepsy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Article
- State and trait characteristics of anterior insula time-varying functional connectivity.NeuroImage · 2020Article
Corrections and comments
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Authors and funding
4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Human brain dynamics and functional connectivity fluctuate over a range of temporal scales in coordination with internal states and environmental demands. However, the neurobiological significance and consequences of functional connectivity dynamics during rest have not yet been established. We show that the coarse-grained clustering of whole-brain dynamic connectivity measured with magnetic resonance imaging reveals discrete patterns (dynamic connectivity states) associated with wakefulness and sleep. We validate this using EEG in healthy subjects and patients with narcolepsy and by matching our results with previous findings in a large collaborative database. We also show that drowsiness may account for previous reports of metastable connectivity states associated with different levels of functional integration. This implies that future studies of transient functional connectivity must independently monitor wakefulness. We conclude that a possible neurobiological significance of dynamic connectivity states, computed at a sufficiently coarse temporal scale, is that of fluctuations in wakefulness.
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