ArticleJournal of the American Society of Nephrology : JASN2017
N-Degradomic Analysis Reveals a Proteolytic Network Processing the Podocyte Cytoskeleton.
Article in Journal of the American Society of Nephrology : JASN, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 43 citations in OpenAlex.
- Loss of S1P Lyase Expression in Human Podocytes Causes a Reduction in Nephrin Expression That Involves PKCδ Activation.International journal of molecular sciences · 2023Article
- Cytoskeletal protein degradation in brain death donor kidneys associates with adverse posttransplant outcomes.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2022Article
- Maintaining proteostasis under mechanical stress.EMBO reports · 2021Review
- Proteolysis and inflammation of the kidney glomerulus.Cell and tissue research · 2021Review
- MANTI: Automated Annotation of Protein N-Termini for Rapid Interpretation of N-Terminome Data Sets.Analytical chemistry · 2021Article
- The tissue proteome in the multi-omic landscape of kidney disease.Nature reviews. Nephrology · 2021Review
- Glomerular Damage in Trichloroethylene-Sensitized Mice: Targeting Cathepsin L-Induced Hyperactive mTOR Signaling.Frontiers in pharmacology · 2021Article
- Structural and functional studies ofThe Journal of biological chemistry · 2020Article
- The Mouse Heart Mitochondria N Terminome Provides Insights into ClpXP-Mediated Proteolysis.Molecular & cellular proteomics : MCP · 2020Article
- A molecular mechanism explaining albuminuria in kidney disease.Nature metabolism · 2020Article
- Proteome Analysis of Isolated Podocytes Reveals Stress Responses in Glomerular Sclerosis.Journal of the American Society of Nephrology : JASN · 2020Article
- ExteNDing Proteome Coverage with Legumain as a Highly Specific Digestion Protease.Analytical chemistry · 2020Article
- FSGS-Causing INF2 Mutation Impairs Cleaved INF2 N-Fragment Functions in Podocytes.Journal of the American Society of Nephrology : JASN · 2020Article
- MOLECULAR DESIGN OF THE KIDNEY FILTRATION BARRIER.Transactions of the American Clinical and Climatological Association · 2020Article
- Sensitive Determination of Proteolytic Proteoforms in Limited Microscale Proteome Samples.Molecular & cellular proteomics : MCP · 2019Article
- A fungal substrate mimicking molecule suppresses plant immunity via an inter-kingdom conserved motif.Nature communications · 2019Article
- Nephrin Signaling in the Podocyte: An Updated View of Signal Regulation at the Slit Diaphragm and Beyond.Frontiers in endocrinology · 2018Review
- The protective effect of the EP2 receptor on TGF-β1 induced podocyte injury via the PI3K / Akt signaling pathway.PloS one · 2018Article
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Authors and funding
16 authors at 7 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Regulated intracellular proteostasis, controlled in part by proteolysis, is essential in maintaining the integrity of podocytes and the glomerular filtration barrier of the kidney. We applied a novel proteomics technology that enables proteome-wide identification, mapping, and quantification of protein N-termini to comprehensively characterize cleaved podocyte proteins in the glomerulus
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.