ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2017
Depressed Synaptic Transmission and Reduced Vesicle Release Sites in Huntington's Disease Neuromuscular Junctions.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 22 citations in OpenAlex.
- Integrated effects of altered action potentials and calcium release on skeletal muscle force generation in transgenic Huntington's disease mice.Pflugers Archiv : European journal of physiology · 2026Article
- Article
- Inferring synaptic transmission from the stochastic dynamics of the quantal content: An analytical approach.PLoS computational biology · 2025Article
- Therapeutic approaches targeting aging and cellular senescence in Huntington's disease.CNS neuroscience & therapeutics · 2024Review
- Huntingtin regulates calcium fluxes in skeletal muscle.The Journal of general physiology · 2023Article
- Integrated analysis on transcriptome and behaviors defines HTT repeat-dependent network modules in Huntington's disease.Genes & diseases · 2022Article
- Homeostatic Plasticity of the Mammalian Neuromuscular Junction.Advances in neurobiology · 2022Article
- Acetylcholine receptor subunit expression in Huntington's disease mouse muscle.Biochemistry and biophysics reports · 2021Article
- The mitochondrial biogenesis signaling pathway is a potential therapeutic target for myasthenia gravis via energy metabolism (Review).Experimental and therapeutic medicine · 2021Review
- Mechanisms of exercise as a preventative measure to muscle wasting.American journal of physiology. Cell physiology · 2021Review
- A mouse model of Huntington's disease shows altered ultrastructure of transverse tubules in skeletal muscle fibers.The Journal of general physiology · 2021Article
- Molecular Mechanisms Underlying Muscle Wasting in Huntington's Disease.International journal of molecular sciences · 2020Review
- Mechanisms of altered skeletal muscle action potentials in the R6/2 mouse model of Huntington's disease.American journal of physiology. Cell physiology · 2020Article
- No symphony without bassoon and piccolo: changes in synaptic active zone proteins in Huntington's disease.Acta neuropathologica communications · 2020Article
- Depressed neuromuscular transmission causes weakness in mice lacking BK potassium channels.The Journal of general physiology · 2020Article
- Neurodegenerative diseases: model organisms, pathology and autophagy.Journal of genetics · 2018Review
- Levator Auris Longus Preparation for Examination of Mammalian Neuromuscular Transmission Under Voltage Clamp Conditions.Journal of visualized experiments : JoVE · 2018Article
- Abnormalities in the Motor Unit of a Fast-Twitch Lower Limb Skeletal Muscle in Huntington's Disease.ASN neuroArticle
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Huntington's disease (HD) is a progressive and fatal degenerative disorder that results in debilitating cognitive and motor dysfunction. Most HD studies have focused on degeneration of the CNS. We previously discovered that skeletal muscle from transgenic R6/2 HD mice is hyperexcitable due to decreased chloride and potassium conductances. The progressive and early onset of these defects suggest a primary myopathy in HD. In this study, we examined the relationship between neuromuscular transmission and skeletal muscle hyperexcitability. We used an
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.