Evidence map›Paper›PMID 28724747›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2017

Interleukin-1 Receptor in Seizure Susceptibility after Traumatic Injury to the Pediatric Brain.

Bridgette D Semple, Terence J O'Brien, Kayleen Gimlin, David K Wright, Shi Eun Kim, Pablo M Casillas-Espinosa, Kyria M Webster, Steven Petrou, Linda J Noble-Haeusslein

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed, 1 pooled it
6.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

83 citing papers in PubMed, 1 synthesis or guideline pooled it, 130 citations in OpenAlex.

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  18. Increased Expression of KNeurochemical research · 2024
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23 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Bridgette D SempleDepartment of Medicine (Royal Melbourne Hospital), Melbourne Brain Centre, University of Melbourne, Parkville, 3050 Victoria, Australia, Bridgette.Semple@unimelb.edu.au.
Terence J O'BrienDepartment of Medicine (Royal Melbourne Hospital), Melbourne Brain Centre, University of Melbourne, Parkville, 3050 Victoria, Australia.
Kayleen GimlinDepartment of Neurological Surgery, University of California, San Francisco, California 94143.
David K WrightFlorey Institute of Neuroscience and Mental Health, Parkville, 3050 Victoria, Australia, and.
Shi Eun KimDepartment of Medicine (Royal Melbourne Hospital), Melbourne Brain Centre, University of Melbourne, Parkville, 3050 Victoria, Australia.
Pablo M Casillas-EspinosaDepartment of Medicine (Royal Melbourne Hospital), Melbourne Brain Centre, University of Melbourne, Parkville, 3050 Victoria, Australia.
Kyria M WebsterDepartment of Medicine (Royal Melbourne Hospital), Melbourne Brain Centre, University of Melbourne, Parkville, 3050 Victoria, Australia.
Steven PetrouFlorey Institute of Neuroscience and Mental Health, Parkville, 3050 Victoria, Australia, and.
Linda J Noble-HaeussleinDepartment of Neurological Surgery, University of California, San Francisco, California 94143.
University of Melbourne · AUFlorey Institute of Neuroscience and Mental Health · AUThe Royal Melbourne Hospital · AUNeurological Surgery · USUniversity of California, San Francisco · US

Funding

Trauma to Developing Brain-Injury and Repair MechanismsR01NS050159 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NOBLE, LINDA J. · 2005 to 2013
$2.8M
Determinants of vulnerability and recovery after trauma to the developing brainR01NS077767 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NOBLE, LINDA J. · 2012 to 2016
$1.7M
NINDS NIH HHS R01 NS050159NINDS NIH HHS R01 NS077767
6 · The paper itself

Abstract

Epilepsy after pediatric traumatic brain injury (TBI) is associated with poor quality of life. This study aimed to characterize post-traumatic epilepsy in a mouse model of pediatric brain injury, and to evaluate the role of interleukin-1 (IL-1) signaling as a target for pharmacological intervention. Male mice received a controlled cortical impact or sham surgery at postnatal day 21, approximating a toddler-aged child. Mice were treated acutely with an IL-1 receptor antagonist (IL-1Ra; 100 mg/kg, s.c.) or vehicle. Spontaneous and evoked seizures were evaluated from video-EEG recordings. Behavioral assays tested for functional outcomes, postmortem analyses assessed neuropathology, and brain atrophy was detected by

Indexed as

Age FactorsAnimalsBrainBrain Injuries, TraumaticDisease SusceptibilityHumansInjections, SubcutaneousMaleMiceMice, Inbred C57BLNeuroimagingReceptors, Interleukin-1Recombinant ProteinsSeizuresReceptors, Interleukin-1Recombinant Proteinscytokineinterleukinneurotraumapediatricseizuretraumatic brain injury

Identifiers

PMID28724747
PMCPMC5559762
OpenAlexW2739211306

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.