ArticleProceedings. Biological sciences2017
Stress hormones predict a host superspreader phenotype in the West Nile virus system.
Article in Proceedings. Biological sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 43 citations in OpenAlex.
- Ecological countermeasures to prevent pathogen spillover and subsequent pandemics.Nature communications · 2024Review
- HPA flexibility andPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- The impact of stress and anesthesia on animal models of infectious disease.Frontiers in veterinary science · 2023Review
- Cellular and immunological mechanisms influence host-adapted phenotypes in a vector-borne microparasite.Proceedings. Biological sciences · 2022Article
- Viral Metagenomic Data Analyses of Five New World Bat Species from Argentina: Identification of 35 Novel DNA Viruses.Microorganisms · 2022Article
- Stress in paradise: effects of elevated corticosterone on immunity and avian malaria resilience in a Hawaiian passerine.The Journal of experimental biology · 2021Article
- Land use-induced spillover: a call to action to safeguard environmental, animal, and human health.The Lancet. Planetary health · 2021Article
- Implications of Zoonoses From Hunting and Use of Wildlife in North American Arctic and Boreal Biomes: Pandemic Potential, Monitoring, and Mitigation.Frontiers in public health · 2021Review
- Towards a mechanistic understanding of competence: a missing link in diversity-disease research.Parasitology · 2020Article
- Urinary Cortisol Increases During a Respiratory Outbreak in Wild Chimpanzees.Frontiers in veterinary science · 2020Article
- Reframing conservation physiology to be more inclusive, integrative, relevant and forward-looking: reflections and a horizon scan.Conservation physiology · 2020Article
- Viral Diversity of Microbats within the South West Botanical Province of Western Australia.Viruses · 2019Article
- Light pollution increases West Nile virus competence of a ubiquitous passerine reservoir species.Proceedings. Biological sciences · 2019Article
- Topic modeling of major research themes in disease ecology of mammals.Journal of mammalogy · 2019Article
- Exogenous glucocorticoids amplify the costs of infection by reducing resistance and tolerance, but effects are mitigated by co-infection.Proceedings. Biological sciences · 2019Article
- Extreme Competence: Keystone Hosts of Infections.Trends in ecology & evolution · 2019Review
- Distinct effects of acute versus chronic corticosterone exposure on Zebra finch responses to West Nile virus.Conservation physiology · 2019Article
- Article
- Stress hormones predict a host superspreader phenotype in the West Nile virus system.Proceedings. Biological sciences · 2017Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glucocorticoid stress hormones, such as corticosterone (CORT), have profound effects on the behaviour and physiology of organisms, and thus have the potential to alter host competence and the contributions of individuals to population- and community-level pathogen dynamics. For example, CORT could alter the rate of contacts among hosts, pathogens and vectors through its widespread effects on host metabolism and activity levels. CORT could also affect the intensity and duration of pathogen shedding and risk of host mortality during infection. We experimentally manipulated songbird CORT, asking how CORT affected behavioural and physiological responses to a standardized West Nile virus (WNV) challenge. Although all birds became infected after exposure to the virus, only birds with elevated CORT had viral loads at or above the infectious threshold. Moreover, though the rate of mortality was faster in birds with elevated CORT compared with controls, most hosts with elevated CORT survived past the day of peak infectiousness. CORT concentrations just prior to inoculation with WNV and anti-inflammatory cytokine concentrations following viral exposure were predictive of individual duration of infectiousness and the ability to maintain physical performance during infection (i.e. tolerance), revealing putative biomarkers of competence. Collectively, our results suggest that glucocorticoid stress hormones could directly and indirectly mediate the spread of pathogens.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.