Evidence map›Paper›PMID 28724724›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

BRCT-domain protein BRIT1 influences class switch recombination.

Wei-Feng Yen, Ashutosh Chaudhry, Bharat Vaidyanathan, William T Yewdell, Joseph N Pucella, Rahul Sharma, Yulong Liang, Kaiyi Li, Alexander Y Rudensky, Jayanta Chaudhuri

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Wei-Feng YenImmunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Ashutosh ChaudhryImmunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Bharat VaidyanathanImmunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
William T YewdellImmunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Joseph N PucellaImmunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Rahul SharmaImmunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Yulong LiangThe Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030.ORCID http://orcid.org/0000-0001-8219-9575
Kaiyi LiThe Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030.
Alexander Y RudenskyImmunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Jayanta ChaudhuriImmunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065; chaudhuj@mskcc.org.
Memorial Sloan Kettering Cancer Center · USBaylor College of Medicine · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Training and Career Development and Education CoreU54CA137788 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Daniel Alan Heller · 2008 to 2026
$28.1M
Mechanistic Elucidation of Class Switch Recombination and Somatic HypermutationR01AI072194 · NIAID · SLOAN-KETTERING INST CAN RESEARCH · PI CHAUDHURI, JAYANTA · 2009 to 2025
$6.9M
RNA-directed targeting of AID in immunity and genomic integrityR01AI124186 · NIAID · SLOAN-KETTERING INST CAN RESEARCH · PI Jayanta Chaudhuri · 2016 to 2026
$4.8M
IMMUNOLOGY RESEARCH TRAININGT32CA009149 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI RUDENSKY, ALEXANDER Y · 1985 to 2022
$4.0M
Characterization and targeting BRIT1 deficiency in breast cancerR01CA155151 · NCI · BAYLOR COLLEGE OF MEDICINE · PI LI, KAIYI · 2011 to 2015
$1.6M
NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA155151NCI NIH HHS T32 CA009149NCI NIH HHS U54 CA137788NIAID NIH HHS R01 AI072194NIAID NIH HHS R01 AI124186
6 · The paper itself

Abstract

DNA double-strand breaks (DSBs) serve as obligatory intermediates for Ig heavy chain (

Indexed as

B cellsBRCT domainsclass switch recombinationDNA repairMDC1

Identifiers

PMID28724724
PMCPMC5547652
OpenAlexW2737111160

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.