ArticleJournal of the American Heart Association2017
Dynamic Relation of Changes in Weight and Indices of Fat Distribution With Cardiac Structure and Function: The Dallas Heart Study.
Article in Journal of the American Heart Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Risk of Heart Failure between Different Metabolic States of Health and Weight: A Meta-Analysis of Cohort Studies.Nutrients · 2022Pooled it
- Changes in body mass index and waist circumference and heart failure in type 2 diabetes mellitus.Frontiers in endocrinology · 2023Trial
- Trial
- Adult weight change across the life course and cardiovascular disease prevalence and mortality: a population-based study.Frontiers in public health · 2026Article
- Visceral Adipose Tissue Cut Points for Increased Metabolic Risk in Chinese Adults Using Low-Dose Computed Tomography: A Nationwide Multicenter Study.Obesity facts · 2026Article
- Effect of fat distribution on left ventricular structure and function in different sexes: a Mendelian randomization study.Frontiers in endocrinology · 2025Article
- Exploring the Mechanistic Link Between Obesity and Heart Failure.Current diabetes reports · 2023Review
- Diabesity in Elderly Cardiovascular Disease Patients: Mechanisms and Regulators.International journal of molecular sciences · 2022Review
- Causal effect of central obesity on left ventricular structure and function in preserved EF population: A Mendelian randomization study.Frontiers in cardiovascular medicine · 2022Article
- Cross-Sectional Associations of Objectively Measured Sedentary Time, Physical Activity, and Fitness With Cardiac Structure and Function: Findings From the Dallas Heart Study.Journal of the American Heart Association · 2021Article
- Arterial and Cardiac Remodeling Associated With Extra Weight Gain in an Isolated Abdominal Obesity Cohort.Frontiers in cardiovascular medicine · 2021Article
- Changes in Firefighter Weight and Cardiovascular Disease Risk Factors over Five Years.Medicine and science in sports and exercise · 2020Observational
- Body Fat Distribution, Overweight, and Cardiac Structures in School-Age Children: A Population-Based Cardiac Magnetic Resonance Imaging Study.Journal of the American Heart Association · 2020Article
- Effects of epicardial adipose tissue volume and density on cardiac structure and function in patients free of coronary artery disease.Japanese journal of radiology · 2020Article
- Physical Activity and Incident Heart Failure in High-Risk Subgroups: The ARIC Study.Journal of the American Heart Association · 2020Observational
- Unfavorable perceived neighborhood environment associates with less routine healthcare utilization: Data from the Dallas Heart Study.PloS one · 2020Article
- Determinants of body fat distribution in humans may provide insight about obesity-related health risks.Journal of lipid research · 2019Review
- Gender-specific contribution of cardiometabolic index and lipid accumulation product to left ventricular geometry change in general population of rural China.BMC cardiovascular disorders · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
backgroundObesity may increase heart failure risk through cardiac remodeling. Cross-sectional associations between adiposity and cardiac structure and function have been elucidated, but the impact of longitudinal changes in adiposity on cardiac remodeling is less well understood. METHODS AND
resultsParticipants in the Dallas Heart Study without cardiovascular disease or left ventricular dysfunction underwent assessment of body weight, anthropometrics, and cardiac magnetic resonance imaging at baseline and 7 years later. Associations between changes in indices of generalized and central adiposity with changes in left ventricular mass, volume, mass/volume ratio (concentricity), wall thickness, and ejection fraction were assessed using multivariable linear regression. The study cohort (n=1262) mean age was 44 years with 57% women, 44% black, and 36% obese participants. At follow-up, 41% had ≥5% weight gain, and 15% had ≥5% weight loss. Greater weight gain was associated with younger age, lower risk factor burden, and lower body mass index at baseline. In multivariable models adjusting for age, sex, race, comorbid conditions at baseline and follow-up, baseline adiposity, and cardiac measurement, increasing weight was associated with increases in left ventricular mass (β=0.10,
conclusionsConcentric left ventricular remodeling is the predominant phenotype linked to increasing adiposity in middle age. Our findings support the importance of weight management to prevent secular changes in adiposity, concentric remodeling, and eventual heart failure over time.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.