Evidence map›Paper›PMID 28724556›Full record

ArticleJournal of clinical microbiology2017

Performance Assessment of a Trypanosoma cruzi Chimeric Antigen in Multiplex Liquid Microarray Assays.

Fred Luciano Neves Santos, Paola Alejandra Fiorani Celedon, Nilson Ivo Tonin Zanchin, Amanda Leitolis, Sandra Crestani, Leonardo Foti, Wayner Vieira de Souza, Yara de Miranda Gomes, Marco Aurélio Krieger

Open access · bronzeAbstract read
In one paragraph

Article in Journal of clinical microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Double-antigen sandwich ELISA based on chimeric antigens for detection of antibodies to Trypanosoma cruzi in human sera - A phase II study.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Article
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  8. Article
  9. Chagas Disease: A Silent Threat for Dogs and Humans.International journal of molecular sciences · 2024
    Review
  10. Article
  11. Article
  12. Article
  13. Performance of ChimericFrontiers in medicine · 2022
    Article
  14. Chagas Immunochromatographic Rapid Test in the Serological Diagnosis ofFrontiers in cellular and infection microbiology · 2022
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Fred Luciano Neves SantosGonçalo Moniz Institute, FIOCRUZ-BA, Salvador, Bahia, Brazil fred.santos@bahia.fiocruz.br.ORCID 0000-0002-3944-0818
Paola Alejandra Fiorani CeledonMolecular Biology Institute of Paraná, Curitiba, Paraná, Brazil.
Nilson Ivo Tonin ZanchinCarlos Chagas Institute, FIOCRUZ-PR, Curitiba, Paraná, Brazil.
Amanda LeitolisMolecular Biology Institute of Paraná, Curitiba, Paraná, Brazil.
Sandra CrestaniMolecular Biology Institute of Paraná, Curitiba, Paraná, Brazil.
Leonardo FotiMolecular Biology Institute of Paraná, Curitiba, Paraná, Brazil.
Wayner Vieira de SouzaAggeu Magalhães Institute, FIOCRUZ-PE, Recife, Pernambuco, Brazil.
Yara de Miranda GomesAggeu Magalhães Institute, FIOCRUZ-PE, Recife, Pernambuco, Brazil.
Marco Aurélio KriegerMolecular Biology Institute of Paraná, Curitiba, Paraná, Brazil.
Instituto de Biologia Molecular do Paraná · BRFundação Oswaldo Cruz · BRFundação Carlos Chagas · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diagnosing chronic Chagas disease (CD) requires antibody-antigen detection methods, which are traditionally based on enzymatic assay techniques whose performance depend on the type and quality of antigen used. Previously, 4 recombinant chimeric proteins from the Instituto de Biologia Molecular do Paraná (IBMP-8.1 to 8.4) comprising immuno-dominant regions of diverse

Indexed as

Antibodies, ProtozoanAntigens, ProtozoanChagas DiseaseCross ReactionsEnzyme-Linked Immunosorbent AssayFalse Negative ReactionsHumansLeishmaniaMicroarray AnalysisRecombinant ProteinsTrypanosoma cruziAntibodies, ProtozoanAntigens, ProtozoanRecombinant Proteinschimeric antigenshuman Chagas diseaseliquid microarraysingleplex and multiplex assaysTrypanosoma cruzi

Identifiers

PMID28724556
PMCPMC5625379
OpenAlexW2739384285

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.