Evidence map›Paper›PMID 28724541›Full record

ArticleBlood2017

STIM1 and STIM2 cooperatively regulate mouse neutrophil store-operated calcium entry and cytokine production.

Regina A Clemens, Joshua Chong, Derayvia Grimes, Yongmei Hu, Clifford A Lowell

Open access · bronzeAbstract read
In one paragraph

Article in Blood, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 68 citations in OpenAlex.

  1. Article
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  9. Article
  10. Article
  11. Article
  12. Polyethylene Glycols Stimulate CaInternational journal of nanomedicine · 2024
    Article
  13. Article
  14. STIM1 in tumor cell death: angel or devil?Cell death discovery · 2023
    Review
  15. Review
  16. Article
  17. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Regina A ClemensDepartment of Pediatrics, University of California, San Francisco, CA.
Joshua ChongDepartment of Pediatrics, University of California, San Francisco, CA.
Derayvia GrimesDepartment of Pediatrics, Washington University School of Medicine, St. Louis, MO; and.
Yongmei HuDepartment of Laboratory Medicine, University of California, San Francisco, CA.
Clifford A LowellDepartment of Laboratory Medicine, University of California, San Francisco, CA.
University of California, San Francisco · USWashington University in St. Louis · US

Funding

Pediatric Scientist Development Program (PSDP) [K12]K12HD000850 · NICHD · YALE UNIVERSITY · PI Sallie R. Permar · 1987 to 2026
$44.1M
Mechanisms of Neutrophil ActivationR01AI065495 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LOWELL, CLIFFORD A · 2005 to 2017
$3.7M
Signaling by Cytoplasmic Tyrosine Kinases in LeukocytesR01AI068150 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LOWELL, CLIFFORD A · 2006 to 2016
$3.4M
Regulation of Innate Immune Signaling by Lyn KinaseR01AI113272 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LOWELL, CLIFFORD A · 2015 to 2019
$2.0M
THE MOLECULAR REGULATION OF NEUTROPHIL CALCIUM SIGNALING IN ACUTE LUNG INJURYK08AI119134 · NIAID · WASHINGTON UNIVERSITY · PI CLEMENS, REGINA · 2015 to 2018
$714k
NIAID NIH HHS K08 AI119134NIAID NIH HHS R01 AI065495NIAID NIH HHS R01 AI068150NIAID NIH HHS R01 AI113272NICHD NIH HHS K12 HD000850
6 · The paper itself

Abstract

Neutrophils are key effector cells of the innate immune system. Calcium-dependent signaling pathways initiated by store-operated calcium entry (SOCE) are known to regulate neutrophil activation; however, the precise mechanism of this process remains unclear. STIM1 and STIM2 are calcium-sensing molecules that link calcium depletion of the endoplasmic reticulum with opening of plasma membrane calcium channels. Although a role for STIM1 in neutrophil SOCE and activation has been established, the function of STIM2 is unknown. Here we use mice with conditional ablation of

Indexed as

Neutrophil ActivationAnimalsCalciumCalcium ChannelsCytokinesMiceOxidation-ReductionStromal Interaction Molecule 1Stromal Interaction Molecule 2CalciumCalcium ChannelsCytokinesStim1 protein, mouseStim2 protein, mouseStromal Interaction Molecule 1Stromal Interaction Molecule 2

Identifiers

PMID28724541
PMCPMC5620414
OpenAlexW2736658962

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.