ArticleJournal of the American Association for Laboratory Animal Science : JAALAS2017
Murine Astrovirus Infection and Transmission in Neonatal CD1 Mice.
Article in Journal of the American Association for Laboratory Animal Science : JAALAS, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Pooled it
- Astroviruses use mucus secretion as a novel form of viral egress.PLoS pathogens · 2026Article
- Maintaining Welfare While Extending Cage-Change Intervals: A Performance-Based Study in IVC-Housed Mice.Journal of the American Association for Laboratory Animal Science : JAALAS · 2026Article
- Institutional Cost Savings and Improved Pathogen Detection by Replacing Sentinel Mice with Environmental Soiled Bedding Health Monitoring Methods.Journal of the American Association for Laboratory Animal Science : JAALAS · 2025Article
- Rodent Pathogen Detection via Testing of Soiled Nesting Material.Journal of the American Association for Laboratory Animal Science : JAALAS · 2025Article
- Murine astrovirus infection course and antibody response in different mouse strains.Lab animal · 2025Article
- Novel murine model of human astrovirus infection reveals cardiovascular tropismJournal of virology · 2025Article
- Structure and immunogenicity of the murine astrovirus capsid spike.The Journal of general virology · 2023Article
- Indoleamine 2,3-dioxygenase 1 regulates cell permissivity to astrovirus infection.Mucosal immunology · 2023Article
- Article
- Research-Relevant Conditions and Pathology of Laboratory Mice, Rats, Gerbils, Guinea Pigs, Hamsters, Naked Mole Rats, and Rabbits.ILAR journal · 2021Review
- Biology and Cellular Tropism of a Unique Astrovirus Strain: Murine Astrovirus 2.Comparative medicine · 2021Article
- Characterization of the Eukaryotic Virome of Mice from Different Sources.Microorganisms · 2021Article
- Pathogenesis of murine astrovirus in experimentally infected mice.Experimental animals · 2021Article
- PCR and RT-PCR in the Diagnosis of Laboratory Animal Infections and in Health Monitoring.Journal of the American Association for Laboratory Animal Science : JAALAS · 2020Article
- Serendipitous Discovery of a Novel Murine Astrovirus Contaminating a Murine Helper T-cell Line and Incapable of Infecting Highly Immunodeficient Mice.Comparative medicine · 2020Article
- Prevalence of murine astrovirus in laboratory animal facilities in Japan.The Journal of veterinary medical science · 2020Article
- Astrovirus and the microbiome.Current opinion in virology · 2019Review
- Characterizing a Murine Model for Astrovirus Using Viral Isolates from Persistently Infected Immunocompromised Mice.Journal of virology · 2019Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Murine astrovirus (MuAstV) is a recently identified, widespread infection among laboratory mice. Our goal was to determine the duration of MuAstV infection, susceptibility of pups, and efficacy of soiled-bedding sentinels and environmental monitoring. Eight CD1 dams and their litters of 3-d-old pups and 8 CD1 dams and their litters of 13-d-old mice were inoculated orally with MuAstV. Neither dams nor offspring demonstrated any clinical signs, and MuAstV had little to no effect on weight gain in pups. MuAstV RNA was detected in feces from 15 of the 16 dams through postnatal day (PND) 21, and 9 dams were still shedding MuAstV at PND 42. MuAstV RNA was highest in intestines of mice. Low levels of MuAstV RNA were sporadically detected in the spleen, liver, and kidney. MuAstV was detected in 97% of feces from 3- to 9-wk-old mice born to infected dams. Several weanlings became pregnant, and intestines from their pups were MuAstV-negative at PND 0 through 5. Weekly swabs of cages housing MuAstV-infected mice were MuAstV-positive through PND 42. Swabs of the rear exhaust manifold of the ventilated rack were MuAstV-positive at 21 through 56 d after inoculation. In addition, 98% of sentinels that received soiled bedding from dams and their litters and 83% of sentinels that received soiled bedding from weaned mice were MuAstV-positive. Feces from most sentinels exposed to soiled bedding that had been stored for 1, 2 or 3 wk before addition of the sentinels were MuAstV-positive.
Indexed as
Identifiers
28724490PMC5517330W2981373834What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.