ArticleJournal of the American Association for Laboratory Animal Science : JAALAS2017
Echocardiographic Parameters of Clinically Normal Geriatric Rhesus Macaques (
Article in Journal of the American Association for Laboratory Animal Science : JAALAS, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 16 citations in OpenAlex.
- The influence of age and captivity on cardiac structure and function in rhesus macaques.GeroScience · 2026Article
- The influence of captivity on cardiac structure and function across age, in rhesus macaques.bioRxiv : the preprint server for biology · 2025Article
- Transcriptomic and genetic profiling in a spontaneous non-human primate model of hypertrophic cardiomyopathy and sudden cardiac death.Scientific reports · 2024Article
- SGLT2 inhibition improves coronary flow velocity reserve and contractility: role of glucagon signaling.Cardiovascular diabetology · 2024Article
- Echocardiographic characterization of age- and sex-associated differences in cardiac function and morphometry in nonhuman primates.GeroScience · 2024Article
- Sex-specific differences and predictors of echocardiographic measures of diastolic dysfunction in rhesus macaques (Macaca mulatta).Journal of medical primatology · 2023Article
- Summary and Assessment of Studies on Cardiac Aging in Nonhuman Primates.Comparative medicine · 2021Article
- Article
- Assessment of Right Ventricular Function, Blood Lactate Levels, and Serum Peptidomics Profiles Associated With Mitral Valve Disease in Dogs.Frontiers in veterinary science · 2021Article
- Heritability and Pedigree Analyses of Hypertrophic Cardiomyopathy in Rhesus Macaques (Frontiers in veterinary science · 2021Article
- Identifying Cardiac Diseases using Cardiac Biomarkers in Rhesus Macaques (Comparative medicine · 2020Article
- Echocardiographic reference intervals with allometric scaling of 823 clinically healthy rhesus macaques (Macaca mulatta).BMC veterinary research · 2020Article
- Echocardiographic evaluation of cardiac function in cynomolgus monkeys over a wide age range.Experimental animals · 2020Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The goal of this study was to generate reference intervals for echocardiographic variables in a population of clinically normal geriatric rhesus macaques (Macaca mulatta). To do this, we studied 51 animals (age, 18-29 y; weight, 5.24-17.04 kg). The normal values for cardiac indices, including geometry and systolic and diastolic function, were determined by 2D, M-mode, spectral Doppler, and tissue Doppler echocardiography under ketamine hydrochloride sedation. Statistical correlations between the echocardiographic parameters and age, body weight, sex, and heart rate were investigated. All echocardiographic indices were acquired, and their reference intervals were established. Multiple weak to strong correlations emerged between variables and echocardiographic parameters, but no moderate or strong correlations between body weight or sex and these parameters were noted. Of the 51 geriatric rhesus macaques evaluated, 36 (71%) fulfilled the criteria for diastolic dysfunction. Valve regurgitation, especially tricuspid regurgitation (43%), and aortic regurgitation (51%) also were common in geriatric rhesus macaques. Although these findings merit follow-up, they are unlikely to have clinical significance given their prevalence in these apparently healthy animals.
Indexed as
Identifiers
28724484PMC5517324W2772887062What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.