Evidence map›Paper›PMID 28724437›Full record

ArticleMolecular cancer2017

The lncRNA CASC15 regulates SOX4 expression in RUNX1-rearranged acute leukemia.

Thilini R Fernando, Jorge R Contreras, Matteo Zampini, Norma I Rodriguez-Malave, Michael O Alberti, Jaime Anguiano, Tiffany M Tran, Jayanth K Palanichamy, Jasmine Gajeton, Nolan M Ung and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers.

0numbers the graph read from it
0cells of the map it votes in
79citing papers in PubMed
5.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

79 citing papers in PubMed, 138 citations in OpenAlex.

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  10. LncRNA LINC00466 Promotes the Progression of Breast CancerCurrent pharmaceutical biotechnology · 2025
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  20. Bronchial epithelium epithelial-mesenchymal plasticity forms aberrant basaloid-like cells in vitro.American journal of physiology. Lung cellular and molecular physiology · 2022
    Article

19 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 9 institutions in 3 countries.

Thilini R FernandoDepartment of Pathology and Laboratory Medicine, UCLA, Los Angeles, USA.
Jorge R ContrerasDepartment of Pathology and Laboratory Medicine, UCLA, Los Angeles, USA.
Matteo ZampiniWomen and Child Health Department- Hematology-Oncology laboratory, University of Padova, Padova, Italy.
Norma I Rodriguez-MalaveDepartment of Pathology and Laboratory Medicine, UCLA, Los Angeles, USA.
Michael O AlbertiDepartment of Pathology and Laboratory Medicine, UCLA, Los Angeles, USA.
Jaime AnguianoDepartment of Pathology and Laboratory Medicine, UCLA, Los Angeles, USA.
Tiffany M TranDepartment of Pathology and Laboratory Medicine, UCLA, Los Angeles, USA.
Jayanth K PalanichamyDepartment of Pathology and Laboratory Medicine, UCLA, Los Angeles, USA.
Jasmine GajetonMicrobiology, Immunology and Molecular Genetics Program, UCLA, Los Angeles, USA.
Nolan M UngDepartment of Pathology and Laboratory Medicine, UCLA, Los Angeles, USA.
Cody J ArosMedical Scientist Training Program, David Geffen School of Medicine, UCLA, Los Angeles, USA.
Ella V WatersDepartment of Pathology and Laboratory Medicine, UCLA, Los Angeles, USA.
David CaseroDepartment of Pathology and Laboratory Medicine, UCLA, Los Angeles, USA.
Giuseppe BassoWomen and Child Health Department- Hematology-Oncology laboratory, University of Padova, Padova, Italy.
Martina PigazziWomen and Child Health Department- Hematology-Oncology laboratory, University of Padova, Padova, Italy.
Dinesh S RaoDepartment of Pathology and Laboratory Medicine, UCLA, Los Angeles, USA. drao@mednet.ucla.edu.
University of Padua · ITCedars-Sinai Medical Center · USAll India Institute of Medical Sciences · INBerkeley College · USCleveland Clinic Lerner College of Medicine · USUCLA Jonsson Comprehensive Cancer CenterUniversity of California, Los Angeles · USUniversity of San Francisco · USWashington University in St. Louis · US

Funding

Women's CancersP30CA016042 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Samuel Wheeler French · 1985 to 2026
$134.5M
Virology CoreP30AI028697 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KITCHEN, SCOTT G · 1991 to 2018
$39.9M
UCLA-Caltech Medical Scientist Training ProgramT32GM008042 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI AJIJOLA, OLUJIMI A, DAWSON, DAVID WAYNE · 1985 to 2023
$29.9M
TUMOR CELL SURFACES AND CHROMOSOMEST32CA009056 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Gay M Crooks, David A. Nathanson · 1985 to 2026
$10.5M
UCLA Tumor Immunology Training ProgramT32CA009120 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Steven M. Dubinett, MICHAEL A TEITELL · 1985 to 2026
$10.3M
UCLA MSD ProgramR25GM055052 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BARBER, PAUL HENRY, HASSON, TAMA W. · 1996 to 2021
$9.2M
Training in Developmental HematologyT32HL086345 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KOHN, DONALD B · 2007 to 2022
$3.8M
Function on Non-Coding RNA, MALAT1, in B-cell development and LymphomaR03CA175426 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RAO, DINESH S · 2014 to 2015
$154k
NCI NIH HHS P30 CA016042NCI NIH HHS R03 CA175426NCI NIH HHS T32 CA009056NCI NIH HHS T32 CA009120NHLBI NIH HHS T32 HL086345NIAID NIH HHS P30 AI028697NIGMS NIH HHS R25 GM055052
6 · The paper itself

Abstract

backgroundLong non-coding RNAs (lncRNAs) play a variety of cellular roles, including regulation of transcription and translation, leading to alterations in gene expression. Some lncRNAs modulate the expression of chromosomally adjacent genes. Here, we assess the roles of the lncRNA CASC15 in regulation of a chromosomally nearby gene, SOX4, and its function in RUNX1/AML translocated leukemia.

resultsCASC15 is a conserved lncRNA that was upregulated in pediatric B-acute lymphoblastic leukemia (B-ALL) with t (12; 21) as well as pediatric acute myeloid leukemia (AML) with t (8; 21), both of which are associated with relatively better prognosis. Enforced expression of CASC15 led to a myeloid bias in development, and overall, decreased engraftment and colony formation. At the cellular level, CASC15 regulated cellular survival, proliferation, and the expression of its chromosomally adjacent gene, SOX4. Differentially regulated genes following CASC15 knockdown were enriched for predicted transcriptional targets of the Yin and Yang-1 (YY1) transcription factor. Interestingly, we found that CASC15 enhances YY1-mediated regulation of the SOX4 promoter.

conclusionsOur findings represent the first characterization of this CASC15 in RUNX1-translocated leukemia, and point towards a mechanistic basis for its action.

Indexed as

AnimalsCell Line, TumorCell ProliferationChildCore Binding Factor Alpha 2 SubunitGene Expression ProfilingGene Expression Regulation, NeoplasticHumansLeukemia, Myeloid, AcuteMicePrecursor Cell Lymphoblastic Leukemia-LymphomaPrognosisPromoter Regions, GeneticRNA, Long NoncodingSOXC Transcription FactorsTranslocation, GeneticCore Binding Factor Alpha 2 SubunitRNA, Long NoncodingRUNX1 protein, humanSOX4 protein, humanSOXC Transcription FactorsYY1 Transcription FactorB-allCASC15ETV6-RUNX1Non-coding RNASOX4

Identifiers

PMID28724437
PMCPMC5517805
OpenAlexW2737600680

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.