Evidence map›Paper›PMID 28724426›Full record

ArticleJournal of translational medicine2017

High expression of ETS2 predicts poor prognosis in acute myeloid leukemia and may guide treatment decisions.

Lin Fu, Huaping Fu, Qingyun Wu, Yifan Pang, Keman Xu, Lei Zhou, Jianlin Qiao, Xiaoyan Ke, Kailin Xu, Jinlong Shi

Open access · goldAbstract read
In one paragraph

Article in Journal of translational medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 31 citations in OpenAlex.

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  9. Identification ofFrontiers in cell and developmental biology · 2021
    Article
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  12. Molecular targeting in acute myeloid leukemia.Journal of translational medicine · 2017
    Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 2 countries.

Lin FuDepartment of Hematology and Lymphoma Research Center, Peking University, Third Hospital, Beijing, 100191, China.
Huaping FuDepartment of Nuclear Medicine, Chinese PLA General Hospital, Beijing, 100853, China.
Qingyun WuDepartment of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221002, China.
Yifan PangDepartment of Medicine, Wil-liam Beaumont Hospital, Royal Oak, MI, 48073, USA.
Keman XuNortheastern University, Boston, MA, 02115, USA.
Lei ZhouDepartment of Hematology, Chinese PLA General Hospital, Beijing, 100853, China.
Jianlin QiaoDepartment of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221002, China.
Xiaoyan KeDepartment of Hematology and Lymphoma Research Center, Peking University, Third Hospital, Beijing, 100191, China. xiaoyank@yahoo.com.
Kailin XuDepartment of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221002, China. lihmd@163.com.
Jinlong ShiDepartment of Hematology, Huaihe Hospital of Henan University, Kaifeng, 475000, China. jinlong_301@163.com.
Xuzhou Medical College · CNChinese PLA General Hospital · CNHenan University Huaihe Hospital and Huaihe Clinical Institute · CNBeaumont Hospital, Royal Oak · USNortheastern University · USPeking University Third Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundETS2 is a downstream effector of the RAS/RAF/ERK pathway, which plays a critical role in the development of malignant tumor. However, the clinical impact of ETS2 expression in AML remains unknown.

methodsIn this study, we evaluated the prognostic significance of ETS2 expression using two relatively large cohorts of AML patients.

resultsIn the first cohort, compared to low expression of ETS2 (ETS2

conclusionsOur results indicate that ETS2

Indexed as

Clinical Decision-MakingBiomarkers, TumorCase-Control StudiesCohort StudiesDisease-Free SurvivalFemaleGene Expression ProfilingGene Expression Regulation, LeukemicHumansLeukemia, Myeloid, AcuteMaleMiddle AgedMultivariate AnalysisPrognosisProto-Oncogene Protein c-ets-2Biomarkers, TumorETS2 protein, humanProto-Oncogene Protein c-ets-2Allogeneic HCTAMLETS2Prognosis

Identifiers

PMID28724426
PMCPMC5518161
OpenAlexW2738471482

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.