Evidence map›Paper›PMID 28724417›Full record

ArticleBMC bioinformatics2017

Examining the role of unmeasured confounding in mediation analysis with genetic and genomic applications.

Sharon M Lutz, Annie Thwing, Sarah Schmiege, Miranda Kroehl, Christopher D Baker, Anne P Starling, John E Hokanson, Debashis Ghosh

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC bioinformatics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. The Exposome Approach in Allergies and Lung Diseases: Is It Time to Define a Preconception Exposome?International journal of environmental research and public health · 2021
    Review
  6. Article
  7. Review
  8. Genetic Advances in Chronic Obstructive Pulmonary Disease. Insights from COPDGene.American journal of respiratory and critical care medicine · 2019
    Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sharon M LutzDepartment of Biostatistics and Informatics, University of Colorado Anschutz Medical Campus, 13001 E. 17th Place, B119 Bldg. 500 W3128, Aurora, CO, 80045, USA. sharon.lutz@ucdenver.edu.
Annie ThwingDepartment of Biostatistics and Informatics, University of Colorado Anschutz Medical Campus, 13001 E. 17th Place, B119 Bldg. 500 W3128, Aurora, CO, 80045, USA.
Sarah SchmiegeDepartment of Biostatistics and Informatics, University of Colorado Anschutz Medical Campus, 13001 E. 17th Place, B119 Bldg. 500 W3128, Aurora, CO, 80045, USA.
Miranda KroehlDepartment of Biostatistics and Informatics, University of Colorado Anschutz Medical Campus, 13001 E. 17th Place, B119 Bldg. 500 W3128, Aurora, CO, 80045, USA.
Christopher D BakerDepartment of Pediatrics and Pulmonary Medicine, Children's Hospital Colorado, Aurora, CO, USA.
Anne P StarlingDepartment of Epidemiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
John E HokansonDepartment of Epidemiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Debashis GhoshDepartment of Biostatistics and Informatics, University of Colorado Anschutz Medical Campus, 13001 E. 17th Place, B119 Bldg. 500 W3128, Aurora, CO, 80045, USA.

Funding

Genetic Epidemiology of COPDU01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2007 to 2021
$56.9M
Metabolomic signatures of empysema and COPD progression in the COPDGene cohortR01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2012 to 2016
$31.1M
Genetic Epidemiology of COPDU01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2007 to 2021
$20.7M
Common Genetic Pathways Underlying CVD and COPDK01HL125858 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI LUTZ, SHARON MARIE · 2015 to 2019
$721k
Impaired angiogenesis in preterm infants after maternal complications of pregnancyK23HL121090 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI BAKER, CHRISTOPHER D · 2015 to 2017
$542k
NHLBI NIH HHS K01 HL125858NHLBI NIH HHS K23 HL121090NHLBI NIH HHS R01 HL089897NHLBI NIH HHS U01 HL089856NHLBI NIH HHS U01 HL089897
6 · The paper itself

Abstract

backgroundIn mediation analysis if unmeasured confounding is present, the estimates for the direct and mediated effects may be over or under estimated. Most methods for the sensitivity analysis of unmeasured confounding in mediation have focused on the mediator-outcome relationship.

resultsThe Umediation R package enables the user to simulate unmeasured confounding of the exposure-mediator, exposure-outcome, and mediator-outcome relationships in order to see how the results of the mediation analysis would change in the presence of unmeasured confounding. We apply the Umediation package to the Genetic Epidemiology of Chronic Obstructive Pulmonary Disease (COPDGene) study to examine the role of unmeasured confounding due to population stratification on the effect of a single nucleotide polymorphism (SNP) in the CHRNA5/3/B4 locus on pulmonary function decline as mediated by cigarette smoking.

conclusionsUmediation is a flexible R package that examines the role of unmeasured confounding in mediation analysis allowing for normally distributed or Bernoulli distributed exposures, outcomes, mediators, measured confounders, and unmeasured confounders. Umediation also accommodates multiple measured confounders, multiple unmeasured confounders, and allows for a mediator-exposure interaction on the outcome. Umediation is available as an R package at https://github.com/SharonLutz/Umediation A tutorial on how to install and use the Umediation package is available in the Additional file 1.

Indexed as

Confounding Factors, EpidemiologicGenome-Wide Association StudyHumansPrincipal Component AnalysisPulmonary Disease, Chronic ObstructiveSoftwareDirect effectsMediated effectsMediation analysisPopulation stratificationUnmeasured confounding

Identifiers

PMID28724417
PMCPMC5517807

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.