ArticleBMC genomics2017
Genome analysis of E. coli isolated from Crohn's disease patients.
Article in BMC genomics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
- Persistence mechanisms of Crohn's disease-associated adherent invasiveGut microbes · 2025Article
- Genetic and Microbial Analysis of Invasiveness for Escherichia coli Strains Associated With Inflammatory Bowel Disease.Cellular and molecular gastroenterology and hepatology · 2025Article
- Revealing AIEC Virulence Genes Behind the Mask of Antimicrobial Resistance.Cellular and molecular gastroenterology and hepatology · 2025Article
- The Role of Propionate-Induced Rearrangement of Membrane Proteins in the Formation of the Virulent Phenotype of Crohn's Disease-Associated Adherent-InvasiveInternational journal of molecular sciences · 2024Article
- Contribution of Toxin-Antitoxin Systems to Adherent-InvasiveMicroorganisms · 2024Review
- Phage production is blocked in the adherent-invasive Escherichia coli LF82 upon macrophage infection.PLoS pathogens · 2023Article
- Role of adherent invasiveWorld journal of clinical cases · 2022Review
- Genomics and pathotypes of the many faces of Escherichia coli.FEMS microbiology reviews · 2022Article
- Diversity and Adaptations ofMicroorganisms · 2021Article
- Yersiniabactin Siderophore of Crohn's Disease-Associated Adherent-InvasiveInternational journal of molecular sciences · 2021Article
- Escherichia coli-associated granulomatous colitis in dogs treated according to antimicrobial susceptibility profiling.Journal of veterinary internal medicine · 2021Article
- Genome Complexity Browser: Visualization and quantification of genome variability.PLoS computational biology · 2020Article
- Article
- Neutrophil activation by Escherichia coli isolates from human intestine: effects of bacterial hydroperoxidase activity and surface hydrophobicity.FEBS open bio · 2020Article
- Propionate Induces Virulent Properties of Crohn's Disease-AssociatedFrontiers in microbiology · 2020Article
- Review
- Repertoire and Diversity of Toxin - Antitoxin Systems of Crohn's Disease-Associated Adherent-InvasiveFrontiers in microbiology · 2020Article
- Proteomic dataset: Profiling of membrane fraction ofData in brief · 2019Article
- Proteomic dataset: Profiling of cultivatedData in brief · 2019Article
- Genetic diversity of Escherichia coli in gut microbiota of patients with Crohn's disease discovered using metagenomic and genomic analyses.BMC genomics · 2018Article
Corrections and comments
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Authors and funding
25 authors at 8 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEscherichia coli (E. coli) has been increasingly implicated in the pathogenesis of Crohn's disease (CD). The phylogeny of E. coli isolated from Crohn's disease patients (CDEC) was controversial, and while genotyping results suggested heterogeneity, the sequenced strains of E. coli from CD patients were closely related.
resultsWe performed the shotgun genome sequencing of 28 E. coli isolates from ten CD patients and compared genomes from these isolates with already published genomes of CD strains and other pathogenic and non-pathogenic strains. CDEC was shown to belong to A, B1, B2 and D phylogenetic groups. The plasmid and several operons from the reference CD-associated E. coli strain LF82 were demonstrated to be more often present in CDEC genomes belonging to different phylogenetic groups than in genomes of commensal strains. The operons include carbon-source induced invasion GimA island, prophage I, iron uptake operons I and II, capsular assembly pathogenetic island IV and propanediol and galactitol utilization operons.
conclusionsOur findings suggest that CDEC are phylogenetically diverse. However, some strains isolated from independent sources possess highly similar chromosome or plasmids. Though no CD-specific genes or functional domains were present in all CD-associated strains, some genes and operons are more often found in the genomes of CDEC than in commensal E. coli. They are principally linked to gut colonization and utilization of propanediol and other sugar alcohols.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.