Observational studyMedicine2017
The neutrophil-to-lymphocyte ratio could be a good diagnostic marker and predictor of relapse in patients with adult-onset Still's disease: A STROBE-compliant retrospective observational analysis.
Observational study in Medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Bibliometrics analysis on the research status and trends of adult-onset Still's disease: 1921-2021.Frontiers in immunology · 2022Pooled it
- Predictive Factors for Relapse in Still's Disease: A Retrospective Cohort Study of Clinical and Laboratory Biomarkers.Clinical and translational science · 2026Article
- Pathogenic and genetic landscape of Still's disease across ages, with new insights into age-related IL-18 patterns.Arthritis research & therapy · 2026Review
- The neutrophil-to-lymphocyte ratio as a surrogate marker for disease activity in systemic lupus erythematosus: a correlation study using the SLE-DAS.Therapeutic advances in musculoskeletal disease · 2025Article
- The Risk Factors of Refractory Adult-Onset Still's Disease.International journal of hepatology · 2025Article
- The neutrophil-to-C3 ratio: unveiling diagnostic efficacy for lupus nephritis and association with reduced retinal vascular density in systemic lupus erythematosus.Frontiers in pharmacology · 2025Article
- Article
- B cell subsets in adult-onset Still's disease: potential candidates for disease pathogenesis and immunophenotyping.Arthritis research & therapy · 2023Article
- Clinical characteristics and outcome of elderly onset adult-onset Still's disease: A 10-year retrospective study.Journal of translational autoimmunity · 2023Article
- Evaluation of Glycosylated Ferritin in Adult-Onset Still's Disease and Differential Diagnoses.Journal of clinical medicine · 2022Article
- Associated factors with poor treatment response to initial glucocorticoid therapy in patients with adult-onset Still's disease.Arthritis research & therapy · 2022Article
- Strategy and Challenges of Paraclinical Examinations in Adult-Onset Still's Disease.Journal of clinical medicine · 2022Review
- The effectiveness of tocilizumab in treating refractory adult-onset Still's disease with dichotomous phenotypes: IL-18 is a potential predictor of therapeutic response.Clinical rheumatology · 2022Article
- Identification of prognostic factors and construction of a nomogram for patients with relapse/refractory adult-onset Still's disease.Clinical rheumatology · 2021Article
- Dual therapeutic targeting of intra-articular inflammation and intracellular bacteria enhances chondroprotection in septic arthritis.Science advances · 2021Article
- Systemic immune-inflammation index combined with ferritin can serve as a reliable assessment score for adult-onset Still's disease.Clinical rheumatology · 2021Article
- Combination value of biomarkers in discriminating adult onset Still's disease and sepsis.Wiener klinische Wochenschrift · 2021Article
- Prognostic Value of Blood-Based Inflammatory Biomarkers in Secondary Hemophagocytic Lymphohistiocytosis.Journal of clinical immunology · 2020Article
- Commentary: Systemic immune-inflammatory indices and their association with ocular disorders-Do we have economical and reliable biomarkers?Indian journal of ophthalmology · 2020Article
- Adult-onset Still's disease with macrophage activation syndrome diagnosed and treated based on cytokine profiling: a case-based review.Rheumatology international · 2020Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The neutrophil-to-lymphocyte ratio (NLR) is the proportion of absolute neutrophil count to lymphocytes on routine complete blood count (CBC) tests, and has been studied as a simple marker of the systemic inflammatory response. This study was performed to investigate whether the NLR could be used as a tool to diagnose and predict prognosis in cases of adult-onset Still's disease (AOSD).We retrospectively reviewed 164 patients with suspected AOSD. Among 164 patients with suspected AOSD, 37 patients received another diagnosis (such as viral infection) and were compared with the 127 patients who received a diagnosis of AOSD. Laboratory tests including CBCs, ferritin, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) level, and the NLR were evaluated.AOSD patients showed higher neutrophil counts, lower lymphocyte counts, higher NLRs, and higher levels of ferritin, ESR, and CRP than non-AOSD patients (all P < .001). In receiver operating characteristic (ROC) curve analysis of the NLR for diagnosis of AOSD, the area under the curve (AUC) was highest at 0.967 (95% CI = 0.940-0.993) with a cutoff value of 3.08. The cutoff value showed the greatest sensitivity (91.7%), specificity (68.4%), and AUC value (0.967) as a diagnostic tool for AOSD. The NLR and treatment appeared to be significant prognostic factors for relapse, but only age showed a significant relationship with death. Furthermore, the NLR was significantly higher in patients with macrophage activation syndrome than in hemophagocytic lymphohistiocytosis (HLH) patients (P = .007). In ROC analysis, the NLR with a cutoff value of 5.86 showed a sensitivity of 89.4%, specificity of 87.8%, and AUC of 0.794.The NLR can be used as a diagnostic tool and predictor of relapse in AOSD, and for differential diagnosis of HLH.
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