ArticleSubstance abuse
Age of initiation, psychopathology, and other substance use are associated with time to use disorder diagnosis in persons using opioids nonmedically.
Article in Substance abuse. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Opioid Misuse as a Predictor of Alcohol Treatment Outcomes in the COMBINE Study: Mediation by Medication Adherence.Alcoholism, clinical and experimental research · 2018Trial
- Trends of incident stimulant use disorder diagnoses before and after the COVID-19 pandemic in British Columbia (2013-2024): a population-based study.Frontiers in psychiatry · 2026Article
- Prior adolescent oxycodone exposure enhances pain sensitivity following chronic intermittent ethanol in adult female mice.Physiology & behavior · 2025Article
- Associations Between a Primary Care-Delivered Alcohol-Related Brief Intervention and Subsequent Opioid-Related Outcomes.The American journal of psychiatry · 2024Article
- Incidence, Timing and Social Correlates of the Development of Opioid Use Disorder Among Clients Seeking Treatment for an Alcohol Use Problem: Changes Over the Three Waves of the Opioid Epidemic.Substance abuse and rehabilitation · 2024Article
- Prevalence and determinants of opioid use disorder among long-term opiate users in Golestan Cohort Study.BMC psychiatry · 2023Article
- Voluntary alcohol intake alters the motivation to seek intravenous oxycodone and neuronal activation during the reinstatement of oxycodone and sucrose seeking.Scientific reports · 2023Article
- Economic Evaluation Design within the HEAL Prevention Cooperative.Prevention science : the official journal of the Society for Prevention Research · 2023Article
- Polypharmacy and prescription medication use in a population-based sample of adolescent and young adult cancer survivors.Journal of cancer survivorship : research and practice · 2023Article
- Becoming our young people's case managers: caregivers' experiences, needs, and ideas for improving opioid use treatments for young people using opioids.Substance abuse treatment, prevention, and policy · 2022Article
- Influence of COVID-19 pandemic and vaccination on the menstrual cycle: A retrospective study in Hungary.Frontiers in endocrinology · 2022Article
- Factors That Affect Patient Attrition in Buprenorphine Treatment for Opioid Use Disorder: A Retrospective Real-World Study Using Electronic Health Records.Neuropsychiatric disease and treatment · 2021Article
- Initiation of nonmedical use of prescription opioids among high school students.Substance abuse · 2021Article
- The opioid crisis: a contextual, social-ecological framework.Health research policy and systems · 2020Article
- Prescription opioid misuse among adolescents and emerging adults in the United States: A scoping review.Preventive medicine · 2020Article
- Prescription Drug Misuse: Taking a Lifespan Perspective.Substance abuse : research and treatment · 2020Review
- Adolescent Substance Use and the Brain: Behavioral, Cognitive and Neuroimaging Correlates.Frontiers in human neuroscience · 2020Article
- Sources of Misused Prescription Opioids and Their Association with Prescription Opioid Use Disorder in the United States: Sex and Age Differences.Substance use & misuse · 2020Article
- Pain severity and prescription opioid misuse among individuals with chronic pain: The moderating role of alcohol use severity.Drug and alcohol dependence · 2019Article
- Alcohol use disorder and motives for prescription opioid misuse: A latent class analysis.Substance use & misuse · 2019Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
backgroundNonmedical use of prescription opioids (NMUPO) is an ongoing public health challenge, as NMUPO is associated with psychopathology, other drug use, and fatal overdose. These concomitant risks are greatest in those with opioid use disorder (OUD), but the development of NMUPO-related use disorder is poorly understood. The primary aim of this study was to establish factors associated with the development of and time to OUD among persons engaged in NMUPO.
methodsData were from wave 1 of the National Epidemiologic Study on Alcohol and Related Conditions, with 1755 participants endorsing lifetime NMUPO. Analyses used sequential design-based logistic regression for DSM-IV (Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition) opioid dependence correlates, followed by Cox regression of proportional hazards for correlates (e.g., sociodemographics, age of NMUPO initiation, and psychopathology) of time to dependence in those who developed DSM-IV dependence.
resultsEarlier age of NMUPO initiation increased OUD odds (adjusted odds ratio [AOR] = 0.95, 95% confidence interval [CI] = 0.94-0.96) but slowed OUD development (adjusted hazard ratio [AHR] = 1.05, 95% CI = 1.04-1.06) in those who developed OUD (n = 118), after controlling for sociodemographics, psychopathology, and ages of other drug use initiation. Psychopathology and earlier other drug use initiation were associated with higher OUD odds, but only having an alcohol use disorder was associated with shorter time to OUD.
conclusionsEarlier NMUPO initiation is associated with increased odds of OUD, although those with early initiation had a slower progression to OUD. Programs that prevent early NMUPO initiation, which might lower rates of OUD, and/or identify the later initiators at highest risk for rapid OUD development could have great public health benefits.
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