ArticleACS sensors2017
Automated 3-D Printed Arrays to Evaluate Genotoxic Chemistry: E-Cigarettes and Water Samples.
Article in ACS sensors, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Isolation Techniques of Micro/Nano-Scaled Species for Biomedical Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Advances in 3D Gel Printing for Enzyme Immobilization.Gels (Basel, Switzerland) · 2022Review
- The impact of tobacco smoking and electronic cigarette vaping on salivary biomarkers. A comparative study.The Saudi dental journal · 2022Article
- Recent Advances in 3D Printing of Biomedical Sensing Devices.Advanced functional materials · 2022Article
- Self-Healing, Self-Adhesive and Stable Organohydrogel-Based Stretchable Oxygen Sensor with High Performance at Room Temperature.Nano-micro letters · 2022Article
- Metabolites of Tobacco- and E-Cigarette-Related Nitrosamines Can Drive CuChemical research in toxicology · 2020Article
- 3D-Printed Immunosensor Arrays for Cancer Diagnostics.Sensors (Basel, Switzerland) · 2020Review
- Reviewing the oral carcinogenic potential of E-cigarettes using the Bradford Hill criteria of causation.Translational cancer research · 2020Review
- Label-Free Bioelectrochemical Methods for Evaluation of Anticancer Drug Effects at a Molecular Level.Sensors (Basel, Switzerland) · 2020Review
- Smoker motivations and predictors of smoking cessation: lessons from an inpatient smoking cessation programme.Singapore medical journal · 2019Article
- Digital Manufacturing for Microfluidics.Annual review of biomedical engineering · 2019Review
- Advances in Optical Sensing and Bioanalysis Enabled by 3D Printing.ACS sensors · 2018Review
- 3D-printed miniaturized fluidic tools in chemistry and biology.Trends in analytical chemistry : TRAC · 2018Article
- 3D-Printed Biosensor Arrays for Medical Diagnostics.Micromachines · 2018Review
- Fully 3D printed integrated reactor array for point-of-care molecular diagnostics.Biosensors & bioelectronics · 2018Article
- Automated 3D-Printed Microfluidic Array for Rapid Nanomaterial-Enhanced Detection of Multiple Proteins.Analytical chemistry · 2018Article
- Developing Microfluidic Sensing Devices Using 3D Printing.ACS sensors · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
A novel, automated, low cost, three-dimensional (3-D) printed microfluidic array was developed to detect DNA damage from metabolites of chemicals in environmental samples. The electrochemiluminescent (ECL) detection platform incorporates layer-by-layer (LbL) assembled films of microsomal enzymes, DNA and an ECL-emitting ruthenium metallopolymer in ∼10 nm deep microwells. Liquid samples are introduced into the array, metabolized by the human enzymes, products react with DNA if possible, and DNA damage is detected by ECL with a camera. Measurements of relative DNA damage by the array assess the genotoxic potential of the samples. The array analyzes three samples simultaneously in 5 min. Measurement of cigarette and e-cigarette smoke extracts and polluted water samples was used to establish proof of concept. Potentially genotoxic reactions from e-cigarette vapor similar to smoke from conventional cigarettes were demonstrated. Untreated wastewater showed a high genotoxic potential compared to negligible values for treated wastewater from a pollution control treatment plant. Reactivity of chemicals known to produce high rates of metabolite-related DNA damage were measured, and array results for environmental samples were expressed in terms of equivalent responses from these standards to assess severity of possible DNA damage. Genotoxic assessment of wastewater samples during processing also highlighted future on-site monitoring applications.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.