ArticleACS sensors2017
Single-Cell Mechanical Characteristics Analyzed by Multiconstriction Microfluidic Channels.
Article in ACS sensors, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Real-Time Biophysical Phenotyping and Sorting of Transiting Cells Along a Constriction Microchannel.Micromachines · 2026Article
- Immune organoid for cancer immunotherapy.Acta pharmaceutica Sinica. B · 2025Review
- Experimental measurement and numerical modeling of deformation behavior of breast cancer cells passing through constricted microfluidic channels.Microsystems & nanoengineering · 2024Article
- Recent Advances on Cell Culture Platforms for In Vitro Drug Screening and Cell Therapies: From Conventional to Microfluidic Strategies.Advanced healthcare materials · 2023Review
- Measuring cell deformation by microfluidics.Frontiers in bioengineering and biotechnology · 2023Review
- Microfluidic technologies for cell deformability cytometry.Smart medicine · 2022Review
- Deep learning assisted mechanotyping of individual cells through repeated deformations and relaxations in undulating channels.Biomicrofluidics · 2022Article
- Non-invasive acquisition of mechanical properties of cells via passive microfluidic mechanisms: A review.Biomicrofluidics · 2021Review
- A constriction channel analysis of astrocytoma stiffness and disease progression.Biomicrofluidics · 2021Article
- Comparative Study of Prostate Cancer Biophysical and Migratory Characteristics via Iterative Mechanoelectrical Properties (iMEP) and Standard Migration Assays.Sensors and actuators. B, Chemical · 2020Article
- Tumor-on-a-chip for integrating a 3D tumor microenvironment: chemical and mechanical factors.Lab on a chip · 2020Review
- Post-enrichment circulating tumor cell detection and enumeration via deformability impedance cytometry.Biosensors & bioelectronics · 2020Article
- Biophysical phenotyping of cells via impedance spectroscopy in parallel cyclic deformability channels.Biomicrofluidics · 2019Article
- Microfluidic-Based Single-Cell Study: Current Status and Future Perspective.Molecules (Basel, Switzerland) · 2018Review
- Article
- Entrapment of Prostate Cancer Circulating Tumor Cells with a Sequential Size-Based Microfluidic Chip.Analytical chemistry · 2018Article
- Flow-Induced Transport of Tumor Cells in a Microfluidic Capillary Network: Role of Friction and Repeated Deformation.Cellular and molecular bioengineering · 2017Article
- Integrated Microfluidic System for Gene Silencing and Cell Migration.Advanced biosystems · 2017Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
A microfluidic device composed of variable numbers of multiconstriction channels is reported in this paper to differentiate a human breast cancer cell line, MDA-MB-231, and a nontumorigenic human breast cell line, MCF-10A. Differences between their mechanical properties were assessed by comparing the effect of single or multiple relaxations on their velocity profiles which is a novel measure of their deformation ability. Videos of the cells were recorded via a microscope using a smartphone, and imported to a tracking software to gain the position information on the cells. Our results indicated that a multiconstriction channel design with five deformation (50 μm in length, 10 μm in width, and 8 μm in height) separated by four relaxation (50 μm in length, 40 μm in width, and 30 μm in height) regions was superior to a single deformation design in differentiating MDA-MB-231 and MCF-10A cells. Velocity profile criteria can achieve a differentiation accuracy around 95% for both MDA-MB-231 and MCF-10A cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.