ArticleACS nano2017
Structural and Spectroscopic Properties of Assemblies of Self-Replicating Peptide Macrocycles.
Article in ACS nano, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Building Molecules by a Self-Replicator That Catalyzes Acyl Hydrazone Formation.Angewandte Chemie (International ed. in English) · 2026Article
- Influence of Tacticity on the Self-Assembly of Poly(ethylene glycol)-ACS macro letters · 2025Article
- Competitive exclusion among self-replicating molecules curtails the tendency of chemistry to diversify.Nature chemistry · 2025Article
- Simultaneous Formation of a Foldamer and a Self-Replicator by Out-of-Equilibrium Dynamic Covalent Chemistry.Journal of the American Chemical Society · 2024Article
- Review
- Capturing chemical reactions inside biomolecular condensates with reactive Martini simulations.Communications chemistry · 2024Article
- Assessment of the MARTINI 3 Performance for Short Peptide Self-Assembly.Journal of chemical theory and computation · 2024Article
- Enantioselective Self-Replicators.Journal of the American Chemical Society · 2023Article
- Reactive Martini: Chemical Reactions in Coarse-Grained Molecular Dynamics Simulations.Journal of chemical theory and computation · 2023Article
- Hierarchically self-assembled homochiral helical microtoroids.Nature nanotechnology · 2022Article
- Growing single crystals of two-dimensional covalent organic frameworks enabled by intermediate tracing study.Nature communications · 2022Article
- Controlling Exchange Pathways in Dynamic Supramolecular Polymers by Controlling Defects.ACS nano · 2021Article
- Fluorescence Spectroscopy of Porphyrins and Phthalocyanines: Some Insights into Supramolecular Self-Assembly, Microencapsulation, and Imaging Microscopy.Molecules (Basel, Switzerland) · 2021Review
- Self-Sorting in Dynamic Combinatorial Libraries Leads to the Co-Existence of Foldamers and Self-Replicators.Angewandte Chemie (International ed. in English) · 2021Article
- Peptide-Peptide Co-Assembly: A Design Strategy for Functional Detection of C-peptide, A Biomarker of Diabetic Neuropathy.International journal of molecular sciences · 2020Article
- Biomimetic Nanoarchitectures for Light Harvesting: Self-Assembly of Pyropheophorbide-Peptide Conjugates.The journal of physical chemistry letters · 2020Article
- Caught in the Act: Mechanistic Insight into Supramolecular Polymerization-Driven Self-Replication from Real-Time Visualization.Journal of the American Chemical Society · 2020Article
- Emergence of light-driven protometabolism on recruitment of a photocatalytic cofactor by a self-replicator.Nature chemistry · 2020Article
- Spontaneous Emergence of Self-Replicating Molecules Containing Nucleobases and Amino Acids.Journal of the American Chemical Society · 2020Article
- Protobiotic Systems Chemistry Analyzed by Molecular Dynamics.Life (Basel, Switzerland) · 2019Review
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Self-replication at the molecular level is often seen as essential to the early origins of life. Recently a mechanism of self-replication has been discovered in which replicator self-assembly drives the process. We have studied one of the examples of such self-assembling self-replicating molecules to a high level of structural detail using a combination of computational and spectroscopic techniques. Molecular Dynamics simulations of self-assembled stacks of peptide-derived replicators provide insights into the structural characteristics of the system and serve as the basis for semiempirical calculations of the UV-vis, circular dichroism (CD) and infrared (IR) absorption spectra that reflect the chiral organization and peptide secondary structure of the stacks. Two proposed structural models are tested by comparing calculated spectra to experimental data from electron microscopy, CD and IR spectroscopy, resulting in a better insight into the specific supramolecular interactions that lead to self-replication. Specifically, we find a cooperative self-assembly process in which β-sheet formation leads to well-organized structures, while also the aromatic core of the macrocycles plays an important role in the stability of the resulting fibers.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.