ArticleMolecular plant pathology2018
Ralfuranones contribute to mushroom-type biofilm formation by Ralstonia solanacearum strain OE1-1.
Article in Molecular plant pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Pathogenicity and virulence ofVirulence · 2026Review
- Two ferric uptake regulator proteins inApplied and environmental microbiology · 2026Article
- Contribution of a Novel TetR/AcrR Family Transcriptional Regulator RalT of Ralstonia pseudosolanacearum Strain OE1-1 to the Fine-Tuning of Its Virulence.MicrobiologyOpen · 2026Article
- Differential phosphorylation of receptor kinase SlLYK4 mediates immune responses to bacterial and fungal pathogens in tomato.Science advances · 2025Article
- Root exudate monosaccharides modulate the pathogenicity ofFrontiers in microbiology · 2025Article
- Lectins and polysaccharide EPS I have flow-responsive roles in the attachment and biofilm mechanics of plant pathogenic Ralstonia.PLoS pathogens · 2024Article
- N-acyl homoserine lactone cell-cell diffusible signalling in the Ralstonia solanacearum species complex.Molecular plant pathology · 2024Review
- Development of a tomato xylem-mimicking microfluidic system to studyFrontiers in bioengineering and biotechnology · 2024Article
- Quorum Sensing-Dependent Invasion of Ralstonia solanacearum into Fusarium oxysporum Chlamydospores.Microbiology spectrum · 2023Article
- Article
- RasI/R Quorum Sensing System Controls the Virulence ofApplied and environmental microbiology · 2022Article
- Markerless gene deletion inFrontiers in microbiology · 2022Article
- The putative sensor histidine kinase PhcK is required for the full expression of phcA encoding the global transcriptional regulator to drive the quorum-sensing circuit of Ralstonia solanacearum strain OE1-1.Molecular plant pathology · 2020Article
- Major exopolysaccharide, EPS I, is associated with the feedback loop in the quorum sensing of Ralstonia solanacearum strain OE1-1.Molecular plant pathology · 2019Article
- Bioorganic chemistry of signaling molecules in microbial communication.Journal of pesticide science · 2019Article
- Saline Environments as a Source of Potential Quorum Sensing Disruptors to Control Bacterial Infections: A Review.Marine drugs · 2019Review
- Contribution of a lectin, LecM, to the quorum sensing signalling pathway of Ralstonia solanacearum strain OE1-1.Molecular plant pathology · 2019Article
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15 authors.
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Abstract
After invasion into intercellular spaces of tomato plants, the soil-borne, plant-pathogenic Ralstonia solanacearum strain OE1-1 forms mushroom-shaped biofilms (mushroom-type biofilms, mBFs) on tomato cells, leading to its virulence. The strain OE1-1 produces aryl-furanone secondary metabolites, ralfuranones (A, B, J, K and L), dependent on the quorum sensing (QS) system, with methyl 3-hydroxymyristate (3-OH MAME) synthesized by PhcB as a QS signal. Ralfuranones are associated with the feedback loop of the QS system. A ralfuranone productivity-deficient mutant (ΔralA) exhibited significantly reduced growth in intercellular spaces compared with strain OE1-1, losing its virulence. To analyse the function of ralfuranones in mBF formation by OE1-1 cells, we observed cell aggregates of R. solanacearum strains statically incubated in tomato apoplast fluids on filters under a scanning electron microscope. The ΔralA strain formed significantly fewer microcolonies and mBFs than strain OE1-1. Supplementation of ralfuranones A, B, J and K, but not L, significantly enhanced the development of mBF formation by ΔralA. Furthermore, a phcB- and ralA-deleted mutant (ΔphcB/ralA) exhibited less formation of mBFs than OE1-1, although a QS-deficient, phcB-deleted mutant formed mBFs similar to OE1-1. Supplementation with 3-OH MAME significantly reduced the formation of mBFs by ΔphcB/ralA. The application of each ralfuranone significantly increased the formation of mBFs by ΔphcB/ralA supplied with 3-OH MAME. Together, our findings indicate that ralfuranones are implicated not only in the development of mBFs by strain OE1-1, but also in the suppression of QS-mediated negative regulation of mBF formation.
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