ArticleNature immunology2017
A guiding map for inflammation.
Erratum issued Registry-linked trialOpen access · greenAbstract read
In one paragraph
Article in Nature immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT03987776 (The Effect of an Anti-Inflammatory Diet on Weight Loss, Body Composition, Cardiometabolic Risk Factors and Immune System Response in Younger Adults), which is not on this map. Cited by 397 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
397citing papers in PubMed, 3 pooled it
19.3field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of an Anti-Inflammatory Diet on Weight Loss, Body Composition, Cardiometabolic Risk Factors and Immune System Response in Younger Adults
Who cites it
397 citing papers in PubMed, 3 syntheses or guidelines pooled it, 805 citations in OpenAlex.
- GLP-1 and its derivatives are associated with the reduction of macrophage infiltration and inflammation in systemic chronic inflammatory diseases: a systematic review and meta-analysis of animal models.Immunologic research · 2026Pooled it
- The impact of exercise on inflammatory biomarkers: an umbrella review of systematic reviews and meta-analyses.Frontiers in immunology · 2026Pooled it
- The effects of L-carnitine supplementation on inflammatory and anti-inflammatory markers in adults: a systematic review and dose-response meta-analysis.Inflammopharmacology · 2023Pooled it
- Trophoblast Extracellular Vesicles Rewire Immunity: A Symptom-Relief Avenue for Recessive Dystrophic Epidermolysis Bullosa.Journal of extracellular vesicles · 2026Article
- Insights Into Spatial Transcriptomics: Exploring Recent Technical Developments and Their Diverse Applications.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Review
- Halodule uninervis ethanolic extract reduces inflammation in LPS-stimulated RAW 264.7 macrophages via NF-κB, STAT3, and MAPK modulation.Scientific reports · 2026Article
- Interleukin-10-engineered mesenchymal stem/stromal cells exhibit robust immunomodulatory effects in vitro and in vivo.Stem cell research & therapy · 2026Article
- Zfand5 terminates TLR3/4 signaling and necroptosis by targeting TRIF to the proteasome for degradation.Cell death & disease · 2026Article
- Review
- A honeysuckle-decorated nanoimmunomodulator hijacks Macrophage-BMSC crosstalk to promote arthritic regeneration.Materials today. Bio · 2026Article
- Regulator of G protein signaling 10: a critical regulator of chronic systemic inflammation in parkinson's disease.Journal of neuroinflammation · 2026Review
- M2 Macrophage membrane-mediated biomimetic nanoparticles carrying ADAM9 siRNA alleviate renal inflammation and fibrosis via the AKT/NF-κB pathway.Journal of nanobiotechnology · 2026Article
- Novel Organelle-Based Intracellular Immunity with Mechanistic and Therapeutic Implications.Barrier immunity · 2026Article
- Advances in immune cell-based therapeutic agents for the treatment of inflammation-related diseases.Acta pharmaceutica Sinica. B · 2026Review
- Association between self-purchased medication use and gastric disease among Chinese adults: a cross-sectional analysis based on CHARLS 2018 data.BMC public health · 2026Article
- Translating microbial dysbiosis into brain health interventions: a focus on the oral-gut-reproductive inflammatory pathways.Archives of microbiology · 2026Review
- Dissecting temporal regulation of the TLR4-IL-6 axis using systematic targeted inhibition.Scientific reports · 2026Article
- Mast Cells and Substance P: Neuroinflammatory Loops at the Molecular and Translational Clinical Levels.Biomolecules · 2026Review
- Dynamic Lipidomic Responses to Inflammation and Physical Insult: A Comparative Review Across Blunt Force Trauma, Thermal Burn Injury, and Viral Infection.Expert reviews in molecular medicine · 2026Review
- A network analysis of lifetime stressor exposure, mental health, well-being, and immune cell mobilisation to acute stressors in young adults.Brain, behavior, & immunity - health · 2026Article
337 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
32 authors at 20 institutions in 11 countries.
Mihai G NeteaDepartment of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands.
Frances BalkwillBarts Cancer Institute, Queen Mary University of London, London, UK.
Michel ChoncholDivision of Renal Diseases and Hypertension, University of Colorado, Denver, Aurora, Colorado, USA.
Fabio CominelliDigestive Health Research Institute, Case Western Reserve University, Cleveland, Ohio, USA.
Marc Y DonathClinic of Endocrinology, Diabetes and Metabolism, University Hospital, University of Basel, Basel, Switzerland.
Evangelos J Giamarellos-Bourboulis4th Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, Athens, Greece.ORCID http://orcid.org/0000-0003-4713-3911
Douglas GolenbockDivision of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Mark S GresnigtDepartment of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands.ORCID http://orcid.org/0000-0002-9514-4634
Michael T HenekaDepartment of Neurodegenerative Disease and Gerontopsychiatry/Neurology, University of Bonn, Bonn, Germany.
Hal M HoffmanDivision of Pediatric Allergy, Immunology, and Rheumatology, University of California at San Diego and Rady Children's Hospital of San Diego, San Diego, California, USA.
Richard HotchkissDepartment of Anesthesiology, Medicine, and Surgery, Washington University School of Medicine, St Louis, Missouri, USA.
Leo A B JoostenDepartment of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands.
Daniel L KastnerInflammatory Disease Section, Metabolic, Cardiovascular and Inflammatory Disease Genomics Branch, National Human Genome Research Institute, US National Institutes of Health, Bethesda, Maryland, USA.
Martin KorteTU Braunschweig, Zoological Institute and HZI, AG NIND, Braunschweig, Germany.
Eicke LatzDivision of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.ORCID http://orcid.org/0000-0003-1488-5666
Peter LibbyCardiovascular Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Thomas Mandrup-PoulsenDepartment of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
Alberto MantovaniHumanitas Clinica Research Center, Humanitas University, Milano, Italy.ORCID http://orcid.org/0000-0001-5578-236X
Kingston H G MillsSchool of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
Kristen L NowakDivision of Renal Diseases and Hypertension, University of Colorado, Denver, Aurora, Colorado, USA.
Luke A O'NeillSchool of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
Peter PickkersDepartment of Intensive Care Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.
Tom van der PollCenter of Experimental and Molecular Medicine, Division of Infectious Diseases, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
Paul M RidkerCenter for Cardiovascular Disease Prevention, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Joost SchalkwijkDepartment of Dermatology, Radboud University Medical Center, Nijmegen, the Netherlands.
David A SchwartzDivision of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado, Denver, Aurora, Colorado, USA.
Britta SiegmundDepartment of Medicine (Gastroenterology, Infectious Diseases, Rheumatology), Charité-Universitätsmedizin Berlin, Berlin, Germany.
Clifford J SteerDepartments of Medicine and of Genetics, Cell Biology and Development, University of Minnesota Medical School, Minneapolis, Minnesota, USA.
Herbert TilgDepartment of Internal Medicine I, Gastroenterology, Hepatology &Endocrinology, Medical University Innsbruck, Innsbruck, Austria.
Jos W M van der MeerDepartment of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands.
Frank L van de VeerdonkDepartment of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands.
Charles A DinarelloDepartment of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands.
Radboud University Nijmegen · NLUniversity of Colorado Denver · USBrigham and Women's Hospital · USTrinity College Dublin · IEUniversity of Bonn · DEAmsterdam UMC Location University of Amsterdam · NLCase Western Reserve University · USCharité - Universitätsmedizin Berlin · DEHumanitas University · ITInnsbruck Medical University · ATNational and Kapodistrian University of Athens · GRNational Institutes of Health · USQueen Mary University of London · GBRady Children's Hospital-San Diego · USTechnische Universität Braunschweig · DEUniversity of Basel · CHUniversity of Copenhagen · DKUniversity of Massachusetts Chan Medical School · USUniversity of Minnesota · USWashington University in St. Louis · US
Funding
Genetics, Pathophysiology, and Treatment of Recessive Autoinflammatory DiseasesZIAHG200372 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI KASTNER, DANIEL · 2011 to 2025
$27.2MGenetics, Pathophysiology, and Treatment of Dominant Autoinflammatory DiseasesZIAHG200373 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI KASTNER, DANIEL · 2011 to 2024
$21.0MUbiquitination Pathways Mediating Chronic Intestinal InflammationP01DK091222 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI COMINELLI, FABIO · 2011 to 2020
$16.5MRole of Genetics in Idiopathic Pulmonary Fibrosis (IPF)R01HL097163 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI FINGERLIN, TASHA E., SCHWARTZ, DAVID ALBERT · 2009 to 2018
$16.4MThe Cleveland Digestive Diseases Research Core Center (DDRCC)P30DK097948 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI Theresa Torres Pizarro · 2015 to 2026
$15.6MT CELL/CYTOKINE MEDIATED EXPERIMENTAL ILEITISP01DK057880 · NIDDK · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI COHN, STEVEN M · 2000 to 2011
$11.4MYeast-based HTS Assay Technologies for ProteasesR01AI015614 · NIAID · UNIVERSITY OF COLORADO DENVER · PI DINARELLO, CHARLES ANTHONY · 1985 to 2025
$8.5MUVA Digestive Health Research CenterP30DK067629 · NIDDK · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI PIZARRO, THERESA TORRES · 2004 to 2008
$5.6MMolecular Determinants of Arterial Remodeling in AtherogenesisR01HL080472 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LIBBY, PETER · 2005 to 2018
$5.0MMECHANISMS OF EXPERIMENTAL CROHNS DISEASER01DK055812 · NIDDK · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI COMINELLI, FABIO · 1999 to 2019
$4.9MCYTOKINES AND INFLAMMATORY BOWEL DISEASER01DK042191 · NIDDK · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI COMINELLI, FABIO, PIZARRO, THERESA TORRES · 1995 to 2022
$4.7MCYTOKINES AND INFLAMMATORY BOWEL DISEASER37DK042191 · NIDDK · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI COMINELLI, FABIO · 1999 to 2009
$3.8MCancer Research UK 16354Cancer Research UK A16354European Research Council 310372European Research Council 322566European Research Council 669415NHLBI NIH HHS R01 HL080472NHLBI NIH HHS R01 HL097163NHLBI NIH HHS R33 HL120770NIAID NIH HHS R01 AI015614NIAID NIH HHS R21 AI102269NIDDK NIH HHS P01 DK057880NIDDK NIH HHS P01 DK091222NIDDK NIH HHS P30 DK067629NIDDK NIH HHS P30 DK097948NIDDK NIH HHS R01 DK042191NIDDK NIH HHS R01 DK055812NIDDK NIH HHS R01 DK056762NIDDK NIH HHS R01 DK125293NIDDK NIH HHS R37 DK042191NIDDK NIH HHS R56 DK042191NIDDK NIH HHS R56 DK055812NIDDK NIH HHS T35 DK111373
Abstract
Biologists, physicians and immunologists have contributed to the understanding of the cellular participants and biological pathways involved in inflammation. Here, we provide a general guide to the cellular and humoral contributors to inflammation as well as to the pathways that characterize inflammation in specific organs and tissues.
Indexed as
Acute DiseaseChronic DiseaseCommunicable DiseasesHumansImmunity, CellularImmunity, HumoralInflammation
Identifiers
What OpenQuestion holds
Textmetadata
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Read underepoch 390
Registered trials
NCT03987776ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.