Evidence map›Paper›PMID 28722495›Full record

ArticleCancer investigation2017

Sucrose Non-Fermenting Related Kinase Expression in Ovarian Cancer and Correlation with Clinical Features.

Elizabeth E Hopp, Stephanie M Cossette, Suresh N Kumar, Daniel Eastwood, Ramani Ramchandran, Erin Bishop

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer investigation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Elizabeth E Hoppa Department of Obstetrics and Gynecology , Medical College of Wisconsin , Milwaukee , Wisconsin , USA.
Stephanie M Cossetteb Department of Pediatrics, Children's Research Institute, Division of Neonatology , Medical College of Wisconsin , Milwaukee , Wisconsin , USA.
Suresh N Kumarb Department of Pediatrics, Children's Research Institute, Division of Neonatology , Medical College of Wisconsin , Milwaukee , Wisconsin , USA.
Daniel Eastwoodd Division of Biostatistics , Medical College of Wisconsin , Milwaukee , Wisconsin , USA.
Ramani Ramchandrana Department of Obstetrics and Gynecology , Medical College of Wisconsin , Milwaukee , Wisconsin , USA.
Erin Bishopa Department of Obstetrics and Gynecology , Medical College of Wisconsin , Milwaukee , Wisconsin , USA.
Children's Hospital of Wisconsin · USMedical College of Wisconsin · US

Funding

Clinical and Translational Science AwardUL1TR001436 · NCATS · MEDICAL COLLEGE OF WISCONSIN · PI FREED, JULIE K · 2015 to 2025
$47.5M
Targeting DUSP-5 to Treat Vascular AnomaliesR01HL112639 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI RAMCHANDRAN, RAMANI · 2012 to 2016
$2.6M
Snrk-1 and Dusp-5 co-ordinately regulate vascular development in vertebratesR01HL102745 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI RAMCHANDRAN, RAMANI · 2011 to 2014
$1.5M
Clinical and Translational Science AwardKL2TR000056 · NCATS · MEDICAL COLLEGE OF WISCONSIN · PI SHAKER, REZA NONE · 2012 to 2015
$609k
NCATS NIH HHS KL2 TR000056NCATS NIH HHS UL1 TR001436NHLBI NIH HHS R01 HL102745NHLBI NIH HHS R01 HL112639
6 · The paper itself

Abstract

Sucrose non-fermenting related kinase (SNRK) is a serine/threonine kinase known to regulate cellular metabolism and adipocyte inflammation. Since alterations in adipocyte metabolism play a role in ovarian cancer metastasis, we investigated the expression of SNRK in benign and malignant human ovarian tissue using immunohistochemistry and qPCR. The number of SNRK positive (+) nuclei is increased in malignant tissue compared to benign tissue (21.03% versus 14.90%, p < .0431). The most strongly stained malignant SNRK+ nuclei were stage 1 compared to stage 2-4 disease. Differential expression of SNRK in early versus late stage disease suggests specific roles for SNRK in ovarian cancer metastasis.

Indexed as

AdultAgedAged, 80 and overBiomarkers, TumorCarcinoma, Ovarian EpithelialFemaleGene Expression Regulation, EnzymologicGene Expression Regulation, NeoplasticHumansImmunohistochemistryMiddle AgedNeoplasm GradingNeoplasms, Glandular and EpithelialNeoplasm StagingOvarian NeoplasmsProtein Serine-Threonine KinasesBiomarkers, TumorProtein Serine-Threonine KinasesRNA, MessengerSNRK protein, humanCancer biomarkersInvasion & metastasisOvarian cancer

Identifiers

PMID28722495
PMCPMC6167932
OpenAlexW2737425653

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.